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PHR1270

Supelco

富马酸

Pharmaceutical Secondary Standard; Certified Reference Material

同義詞:

富马酸

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About This Item

線性公式:
HOOCCH=CHCOOH
CAS號碼:
110-17-8
分子量：:
116.07
Beilstein:
605763
EC號碼:
203-743-0
MDL號碼:
MFCD00002700
分類程式碼代碼:
41116107
PubChem物質ID:
329823266
NACRES:
NA.24
暫時無法取得訂價和供貨情況

等級

certified reference material
pharmaceutical secondary standard

品質等級

300

agency

traceable to Ph. Eur. F0600000
traceable to USP 1286708

蒸汽壓力

1.7 mmHg ( 165 °C)

API 家族

fumaric acid

CofA

current certificate can be downloaded

自燃溫度

1364 °F

expl. lim.

40 %

技術

HPLC: suitable
gas chromatography (GC): suitable

mp

298-300 °C (subl.) (lit.)

應用

pharmaceutical (small molecule)

形式

neat

儲存溫度

2-8°C

SMILES 字串

OC(=O)\C=C\C(O)=O

InChI

1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+

InChI 密鑰

VZCYOOQTPOCHFL-OWOJBTEDSA-N

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相關類別

一般說明

用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。

應用

富马酸可作为药物参考标准品，通过分光光度法对药物制剂中的分析物进行测定。[1][2]
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

分析報告

这些二级标准品可追溯至USP、EP和BP一级标准品。

其他說明

该认证参考物质（CRM）根据ISO 17034和ISO/IEC 17025进行生产和认证。所有关于该 CRM 的信息都可以在分析证书上找到。

腳註

要查看该材料的分析证书示例，请在下面的栏位中输入 LRAC1693。这只是一个示例证书，可能不是您收到的批次。

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在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析（使用数字化外标）。可查看该物质的NMR谱图，只需点击几次鼠标，就能进行在线样品比对。欢迎点击了解更多，开启免费试用之旅。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H319

防範說明

P305 + P351 + P338

危險分類

Eye Irrit. 2

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

521.6 - 525.2 °F - open cup

閃點（°C）

272 - 274 °C - open cup

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number

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L-天冬氨酸 Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1104

L-天冬氨酸

马来酸 United States Pharmacopeia (USP) Reference Standard

USP

1374500

马来酸

马来酸 European Pharmacopoeia (EP) Reference Standard

M0100000

马来酸

富马酸 FCC, FG

Sigma-Aldrich

W248800

富马酸

L-鸟氨酸 L-天冬氨酸盐 powder

Sigma-Aldrich

O7125

L-鸟氨酸 L-天冬氨酸盐

Spectrophotometric estimation of ketotifen fumarate in pharmaceutical formulations
Sastry CSP and Naidu PY
Microchimica Acta, 127(3-4), 219-223 (1997)
Spectrophotometric determination of ascorbic acid in pharmaceuticals by background correction and flow injection
Verma KK, et al.
Analyst, 116(6), 641-645 (1991)
R Gold et al.
Clinical immunology (Orlando, Fla.), 142(1), 44-48 (2011-03-19)
Fumaric acid was originally therapeutically used in psoriasis. Several lines of evidence have demonstrated immunomodulatory but also neuroprotective effects for FAE. Clinical studies in psoriasis showed a reduction of peripheral CD4+ and CD8+ T-lymphocytes due to the ability of FAE
B Sebók et al.
Orvosi hetilap, 141(3), 129-132 (2000-02-29)
The treatment of psoriasis vulgaris with fumaric acid esters has been controversial for more than 30 years. Recently the fumaric acid derivatives are marketed antipsoriatics in many European countries. In this paper the clinical efficacy, the side effects as well
Management of psoriasis vulgaris and multiple sclerosis with fumaric acid.
Spyridon Gkalpakiotis et al.
Journal of the American Academy of Dermatology, 70(3), e60-e61 (2014-02-18)
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文章

Separation of Organic Acids with 100% aqueous mobile phase using an Ascentis® Express AQ-C18 HPLC Column

A new RP-HPLC method is proposed for the determination of organic acids in 100% aqueous mobile phase using an Ascentis® Express AQ-C18 column

使用Ascentis® Express AQ-C18 HPLC色譜柱，以100%水性流動相分離有機酸。

使用Ascentis® Express AQ-C18色譜柱，提出了一種新的RP-HPLC方法，用於測定100%水溶液流動相中的有機酸。

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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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