Some cells, and in particular cancer cells, may be resistant to 5-fluorouracil. Please see this paper Huanwen, W., et al., Molecular Cancer, 8, 125 (2009) which addresses this observation, as well as references 16 and 30 in this publication.If the cells are treated with the closely related gemcitabine (Sigma-Aldrich Product G6423), and cell growth is not inhibited by that drug either, you will have shown that the "problem" is with the cell line, and not with the drug(s).
推薦產品
等級
certified reference material
pharmaceutical secondary standard
品質等級
agency
traceable to BP 995
traceable to Ph. Eur. F0250000
traceable to USP 12790000
API 家族
fluorouracil
CofA
current certificate can be downloaded
技術
HPLC: suitable
gas chromatography (GC): suitable
mp
282-286 °C (dec.) (lit.)
應用
cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)
形式
neat
儲存溫度
2-30°C
SMILES 字串
FC1=CNC(=O)NC1=O
InChI
1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChI 密鑰
GHASVSINZRGABV-UHFFFAOYSA-N
基因資訊
human ... TYMS(7298)
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一般說明
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Fluorouracil, an analog of the pyrimidines, belongs to the class of antimetabolite drugs. It is generally utilized for the remediation of tumors such as breast adenocarcinoma, gastrointestinal tract, ovary, head and neck.[1]
Fluorouracil, an analog of the pyrimidines, belongs to the class of antimetabolite drugs. It is generally utilized for the remediation of tumors such as breast adenocarcinoma, gastrointestinal tract, ovary, head and neck.[1]
應用
Fluorouracil may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by different analytical techniques.[2][3]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
分析報告
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
其他說明
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
腳註
To see an example of a Certificate of Analysis for this material enter LRAC3468 in the slot below. This is an example certificate only and may not be the lot that you receive.
推薦產品
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
相關產品
產品號碼
描述
訂價
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral - Carc. 2
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
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Why does the 5-Fluorouracil have no effect on my cell line, even at micromolar concentrations that should be more than high enough?
1 answer-
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Do you have 5-FU (5-Fluorouracil) for injection? If not, how can I prepare it from the powder?
1 answer-
Sigma-Aldrich lists several fluorouracil products, but we do not offer Fluorouracil for injection. Our 5-Fluorouracil (5-FU) products cannot be given to human patients. (Note that although Product F8423 meets USP testing specifications, it is not a pharmaceutical grade or PharmaGrade product.)Having said that, a solution for injection into research animals could be prepared the same way as the Fluorouracil Injection, USP is. According to the drugs.com, "Fluorouracil Injection, USP, an antineoplastic anti-metabolite, is a colorless to yellow aqueous sterile, nonpyrogenic injectable solution for intravenous administration. Each mL contains: 50 mg fluorouracil; pH is adjusted to 8.6 to 9.4 with sodium hydroxide".
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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