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F8798

Sigma-Aldrich

叶酸

meets USP testing specifications

同義詞:

N-4-[(2-氨基-4-氧代-1,4-二氢-6-喋啶)甲氨基苯甲酰基]-L-谷氨酸, PteGlu, 维生素 M

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About This Item

經驗公式(希爾表示法):
C19H19N7O6
CAS號碼:
分子量::
441.40
Beilstein:
100781
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
eCl@ss:
34058014
PubChem物質ID:
NACRES:
NA.21
暫時無法取得訂價和供貨情況

生物源

synthetic (organic)

品質等級

agency

USP/NF
meets USP testing specifications

化驗

97.0-102.0% dry basis

形狀

solid

顏色

yellow

mp

>285 °C

應用

cell analysis
pharmaceutical (small molecule)

官能基

amide
amine
carboxylic acid

SMILES 字串

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

InChI 密鑰

OVBPIULPVIDEAO-LBPRGKRZSA-N

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相關類別

一般說明

叶酸,也称为蝶酰-L-谷氨酸,属于维生素 B 群。已经基于核磁共振(NMR)和理论计算报道了溶液中叶酸的构象分析。[1]已经研究了在紫外辐射下光分解的反应动力学。[2]本产品是符合 USP(美国药典)测试规范的高质量药典产品。它可以用于研究和试点研究。

應用

叶酸已被用于研究中,以研究其对丙戊酸(VPA)对母体肝组织引起的毒性的保护作用。[3]它也被用作反相 HPLC 定量血浆叶酸的标准。[4]

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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存取文件庫

Solution structure of folic acid: Molecular mechanics and NMR investigation.
Bonechi C, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 60(7), 1411-1419 (2004)
Ultraviolet photodegradation of folic acid.
Off MK, et al.
Journal of Photochemistry and Photobiology. B, Biology, 80(1), 47-55 (2005)
Ultrastructural investigation of the protective role of folic acid and vitamin E against toxic effects of valproic acid on maternal liver tissue during period of gestation.
Ozlem P Baran et al.
Saudi medical journal, 27(3), 407-409 (2006-03-15)
Carolyn Tam et al.
Obstetrics and gynecology international, 2012, 485179-485179 (2012-04-25)
There are increasing concerns that exposure to unmetabolized folic acid, which results from folic acid intakes that overwhelm the liver's metabolic capacity, may be associated with adverse effects. In this paper, we examined the folic acid status of women of
Tor A Strand et al.
Pediatrics, 135(4), e918-e926 (2015-03-25)
Folate and vitamin B-12 are important for growth. Many children in low- and middle-income countries have inadequate intakes of these nutrients. We undertook a randomized, placebo controlled double-blind trial in 1000 North Indian children, 6 to 35 months of age

文章

Explore folic acid importance in serum-free eukaryotic cell cultures, including CHO cells, and its role in media supplementation.

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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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