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F0253000

氟西汀 盐酸盐

European Pharmacopoeia (EP) Reference Standard

同義詞:

(±)-N-甲基-γ-[4-(三氟甲基)苯氧基]苯丙胺 盐酸盐, LY-110,140 盐酸盐, Prozac®

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About This Item

經驗公式（希爾表示法）:
C17H18F3NO · HCl
CAS號碼:
56296-78-7
分子量：:
345.79
MDL號碼:
MFCD00214288
分類程式碼代碼:
41116107
PubChem物質ID:
329799646
NACRES:
NA.24
暫時無法取得訂價和供貨情況

等級

pharmaceutical primary standard

製造商／商標名

EDQM

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

pharmaceutical

形式

neat

SMILES 字串

CNCCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.[H]Cl

InChI

1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H

InChI 密鑰

GIYXAJPCNFJEHY-UHFFFAOYSA-N

基因資訊

human ... SLC6A4(6532)

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一般說明

本品按现行药典规定交付。所有为支持本产品而提供的信息，包括SDS和任何产品信息单均由药典颁发机构制定并发布。 如需进一步信息和支持，请访问现行药典网站。
盐酸氟西汀是一种选择性血清素再摄取抑制剂，是一种有效的抗抑郁药。[1]

生化／生理作用

选择性羟色胺再摄取抑制剂；抗抑郁剂。

包裝

单位数量：250 mg。可进行调整。本品按药典规定提供。有关当前单位数量，请访问 EDQM参考物质目录。

其他說明

可能适用相应的销售限制。

法律資訊

经 Eli Lilly and Company 授权销售。
Prozac is a registered trademark of Eli Lilly and Co.

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描述
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訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - STOT RE 2 - STOT SE 3

標靶器官

Central nervous system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number

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Sean C Godar et al.
Journal of psychiatric research, 56, 1-9 (2014-06-03)
The termination of serotonin (5-hydroxytryptamine, 5-HT) neurotransmission is regulated by its uptake by the 5-HT transporter (5-HTT), as well as its degradation by monoamine oxidase (MAO)-A. MAO-A deficiency results in a wide set of behavioral alterations, including perseverative behaviors and
Paulina Jedynak et al.
Journal of psychiatric research, 56, 106-111 (2014-06-17)
The neurogenesis hypothesis of major depression has two main facets. One states that the illness results from decreased neurogenesis while the other claims that the very functioning of antidepressants depends on increased neurogenesis. In order to verify the latter, we
Melody V Wu et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(8), 1861-1871 (2014-02-13)
Adult hippocampal neurogenesis is critically implicated in rodent models of stress and anxiety as well as behavioral effects of antidepressants. Whereas similar factors such as psychiatric disorder and antidepressant administration are correlated with hippocampal volume in humans, the relationship between
Kristie T Ota et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(3), 711-718 (2014-09-03)
Major depressive disorder (MDD) is a debilitating and widespread illness that exerts significant personal and socioeconomic consequences. Recent genetic and brain-imaging studies suggest that bicaudal C homolog 1 gene (BICC1), which codes for an RNA-binding protein, may be associated with
Marta M Nowacka et al.
Neuroscience research, 88, 74-83 (2014-09-01)
The aim of the present study was to estimate the influence of antidepressants given chronically on brain-derived neurotrophic factor (BDNF) alterations induced by lipopolysaccharide (LPS) in the amygdala and hippocampus of female rats subjected to chronic social instability stress (CSIS)
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