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Merck
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重要文件

905127

Sigma-Aldrich

cis-1-fluoro-4-OTBS-cyclohexane

≥95%

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About This Item

經驗公式(希爾表示法):
C12H25FOSi
CAS號碼:
分子量::
232.41
分類程式碼代碼:
12352101
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化驗

≥95%

形狀

liquid

儲存溫度

2-8°C

應用

The incorporation of fluorine in agrochemical and pharmaceutical compounds is of high interest due to the ability to fine-tune the polarity, pKA-value, conformation and metabolic stability. Derived from a cis-selective hydrogenation developed by Glorius and coworkers, this fluorinated compound displays a diverse utility as a building block for chemical synthesis. Fluoro-cyclohexanol allows for the straightforward application in organic synthesis, after simple deprotection. It can be utilized to prepare fluorinated analogues of known compounds.

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Mario P Wiesenfeldt et al.
Science (New York, N.Y.), 357(6354), 908-912 (2017-08-12)
All-cis-multifluorinated cycloalkanes exhibit intriguing electronic properties. In particular, they display extremely high dipole moments perpendicular to the aliphatic ring, making them highly desired motifs in material science. Very few such motifs have been prepared, as their syntheses require multistep sequences

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