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Merck
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文件

90281

Supelco

穿心莲内酯

analytical standard

同義詞:

(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone, ent-(3β,12E,14R)-3,14,19-Trihydroxy-8(17),12-labdadien-16,15-olide, Andrographis

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About This Item

經驗公式(希爾表示法):
C20H30O5
CAS號碼:
分子量::
350.45
EC號碼:
MDL號碼:
分類程式碼代碼:
85151701
PubChem物質ID:
NACRES:
NA.24

等級

analytical standard

品質等級

化驗

≥95% (HPLC)

儲存期限

limited shelf life, expiry date on the label

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

food and beverages

格式

neat

SMILES 字串

C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H](C\C=C3/[C@H](O)COC3=O)C(=C)CC[C@H]12

InChI

1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1

InChI 密鑰

BOJKULTULYSRAS-OTESTREVSA-N

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一般說明

Andrographolide is a major bioactive component of Andrographis paniculata Nees. which is a popular Chinese and Indian medicine. It belongs to the terpenoid class of compounds.

應用

Andrographolide may be used as a reference standard for the determination of andrographolide in:
  • Leaves of Andrographis paniculata by soxhlet extraction-recrystallization-column chromatography purification followed by analyses using reversed phase high performance liquid chromatography (RP-HPLC) as well as gas chromatography-mass spectrometry (GC-MS).
  • Roots of Andrographis paniculata by HPLC with diode array detection (DAD), gas chromatography-mass spectrometry (GC-MS) and LC coupled to tandem mass spectrometry (MS/MS) equipped with electrospray ionization (ESI) and multiple reaction monitoring (MRM) mode of detection.
  • Stems of Andrographis paniculata by ultra-HPLC combined coupled to triple quadrupole-linear ion trap mass spectrometry (QqQLIT-ESI-MS/MS) with MRM detection.
  • Rat plasma samples by protein precipitation and subsequent ESI-LC-MS/MS determination using MRM detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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Rapid quantitative analysis of multi-components in Andrographis paniculata using UPLC-QqQLIT-MS/MS: Application to soil sodicity and organic farming.
Chandra P, et al.
Industrial Crops and Products, 83(2), 423-430 (2016)
Determination of six components of Andrographis paniculata extract and one major metabolite of andrographolide in rat plasma by liquid chromatography-tandem mass spectrometry
Wang J, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 951(2), 78-88 (2014)
In vitro metabolism of sodium 9-dehydro-17-hydro-andrographolide-19-yl sulfate in rat liver s9 by liquid chromatography-mass spectrometry method.
Zheng D, et al.
Pharmacognosy magazine, 12(2), S102-S102 (2016)
Anti-dengue efficacy of bioactive andrographolide from Andrographis paniculata (Lamiales: Acanthaceae) against the primary dengue vector Aedes aegypti (Diptera: Culicidae).
Edwin ES, et al.
Acta Tropica, 163(2), 167-178 (2016)
Determination of phytochemicals, antioxidant activity and total phenolic content in Andrographis paniculata using chromatographic methods.
Kurzawa M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 995(2), 101-106 (2015)

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