901991

Dde biotin picolyl azide

• 同義詞: N-[6-(Azidomethyl)-3-pyridinyl]-5-(4,4-dimethyl-2,6-dioxocyclohexylidene)-25-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-21-oxo-8,11,14,17-tetraoxa-4,20-diazapentacosanamide
• 經驗公式（希爾表示法）: C₃₈H₅₇N₉O₉S
• CAS號碼: 2055048-42-3
• 分子量：: 815.98
• MDL號碼: MFCD30458027
• 分類程式碼代碼: 12352125
• NACRES: NA.22

屬性

• 形狀: solid
• 反應適用性: reaction type: click chemistry
• 儲存溫度: −20°C
• SMILES 字串: S1[C@@H]([C@@H]4NC(=O)N[C@@H]4C1)CCCCC(=O)NCCOCCOCCOCCOCCC(=C3C(=O)CC(CC3=O)(C)C)NCCC(=O)Nc2cnc(cc2)CN=[N+]=[N-]
• InChI 密鑰: CYXSXYDLWXHYSI-JKMQWNNCSA-N

描述

應用

Dde biotin picolyl azide is a unique alkyne-reactive, cleavable biotin probe that allows for release of the captured biomolecules from streptavidin under mild conditions. This reagent contains a biotin moiety linked to a picolyl azide moiety through a spacer arm containing a hydrazine-cleavable Dde moiety. Captured biomolecules can be efficiently released, typically >90% with 2% hydrazine in aqueous media.
Dde biotin picolyl azide incorporates a copper-chelating motif that dramatically accelerates the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction under conditions relevant to biomolecular labeling. Discovery of azides with an internal Cu(I)-chelating motif greatly enhances the utility of the CuAAC reaction for various applications. Some examples are monitoring the dynamic glycan biosynthesis in living organisms; sensitive detection of metabolically-labeled proteins, DNAs, and RNAs; and many other applications where rate acceleration and reduced cell toxicity are highly desirable.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable