86541

丙酸睾酮

tested according to Ph. Eur.

• 同義詞: 丙酸睾丸素, 17β-Hydroxy-4-androsten-3-one 17-propionate, 17β-Propionyloxy-4-androsten-3-one, 4-Androsten-17β-ol-3-one 17-propionate
• 經驗公式（希爾表示法）: C₂₂H₃₂O₃
• CAS號碼: 57-85-2
• 分子量：: 344.49
• Beilstein: 3221760
• EC號碼: 200-351-1
• MDL號碼: MFCD00003653
• 分類程式碼代碼: 12352211
• PubChem物質ID: 329769470
• NACRES: NA.21

屬性

• agency: USP/NF; tested according to Ph. Eur.
• 形狀: solid
• 藥物控制: USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada
• SMILES 字串: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])OC(=O)CC
• InChI: 1S/C22H32O3/c1-4-20(24)25-19-8-7-17-16-6-5-14-13-15(23)9-11-21(14,2)18(16)10-12-22(17,19)3/h13,16-19H,4-12H2,1-3H3/t16-,17-,18-,19-,21-,22-/m0/s1
• InChI 密鑰: PDMMFKSKQVNJMI-BLQWBTBKSA-N
• 基因資訊: human ... AR(367) , CYP17A1(1586) ; rat ... Ar(24208)

描述

一般說明

Testosterone propionate is the esterified form of testosterone that is most commonly used in clinical applications for the treatment of hypogonadism, oligospermia, and impotence.[1] 17β-hydroxyl group of propionate is esterified to get this form. It is a fast and short-acting form when compared to enanthate and cypionate forms, which are long-acting esters more commonly used in androgen replacement therapies.[2]

應用

Testosterone propionate has been used:

• to determine the effect of testosterone on the uptake of certain amino acids, such as isoleucine and α-(methylamino)isobutyric acid[3]
• in a study to understand the effects of testosterone on brain aromatase activity in neonatal quail brain[4]
• for testosterone treatment of Celf1 knockout mice in a study to investigate the upregulation of aromatase activity in association with hypogonadism[5]
• to investigate the ontogeny of aromatase-expressing neurons in Japanese quail brain[6]
• to study the effects of in vivo administration of testosterone propionate on fluid reabsorption in the efferent ducts of rat.[7]

生化／生理作用

Testosterone is the major circulating androgen in men and is mainly produced by the testis. A small amount is secreted by the adrenal gland. It is produced from cholesterol in the Leydig cells. Testosterone is metabolized to dihydrotestosterone, a potent androgen that associates with a cytoplasmic receptor protein, to form a complex. This complex is activated and transported into the nucleus, where it triggers several biological responses. It mainly participates in the development of the male phenotype during embryogenesis and at puberty.[8][9][10]

其他說明

可能实行销售限制

安全資訊

• 象形圖: GHS08,GHS07,GHS09
• 訊號詞: Danger
• 危險聲明: H302,H351,H360FD,H400
• 防範說明: P202 - P264 - P270 - P273 - P301 + P312 - P308 + P313
• 危險分類: Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Repr. 1A
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 個人防護裝備: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges