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重要文件

81619

Sigma-Aldrich

四氢嘧啶

≥95.0% (HPLC)

同義詞:

(S)-2-甲基-1,4,5,6-四氢嘧啶-4-羧酸, 刺激物(B)

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About This Item

經驗公式(希爾表示法):
C6H10N2O2
CAS號碼:
分子量::
142.16
Beilstein:
7288977
EC號碼:
MDL號碼:
分類程式碼代碼:
24112111
PubChem物質ID:
NACRES:
NA.21
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品質等級

化驗

≥95.0% (HPLC)

形狀

powder

分子量

142.16 g/mol

儲存條件

dry at room temperature

顏色

white

溶解度

methanol: soluble 10 mg/mL, clear, colorless to almost colorless

SMILES 字串

CC1=N[C@@H](CCN1)C(O)=O

InChI

1S/C6H10N2O2/c1-4-7-3-2-5(8-4)6(9)10/h5H,2-3H2,1H3,(H,7,8)(H,9,10)/t5-/m0/s1

InChI 密鑰

WQXNXVUDBPYKBA-YFKPBYRVSA-N

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一般說明

四氢嘧啶(Ectoine), 全称4,5,6-四氢-2-甲基-4-嘧啶羧酸, 是一种两性氨基酸衍生物,作为相容性渗透保护溶质, 由好氧型、化能异养型和嗜盐性细菌生产, 抵抗渗透压胁迫、辐射和其他不利的 环境条件。[1]

應用

该 四氢嘧啶的实际应用包括酶稳定、 抗炎处理、神经退行性疾病预防和其他 治疗用途。[1]

生化/生理作用

四氢嘧啶可用作酶稳定剂,在温度变化下维持水化和减少酶变性。还可提高双链DNA的高温稳定性。[1]

其他說明

酶和生物大分子的稳定剂[2][3][4]

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Adam Bownik et al.
Arhiv za higijenu rada i toksikologiju, 67(4), 260-265 (2016-12-30)
Ectoine is a compatible water molecule-binding solute (osmoprotectant) produced by several bacterial species in response to osmotic stress and unfavourable environmental conditions. This amino acid derivative can accumulate inside cells at high concentrations without interfering with natural processes and can
Alexander S Reshetnikov et al.
Extremophiles : life under extreme conditions, 15(6), 653-663 (2011-10-06)
The genes of ectoine biosynthesis pathway were identified in six species of aerobic, slightly halophilic bacteria utilizing methane, methanol or methylamine. Two types of ectoine gene cluster organization were revealed in the methylotrophs. The gene cluster ectABC coding for diaminobutyric
Ulrich Sydlik et al.
The European respiratory journal, 41(2), 433-442 (2012-10-27)
The life span of neutrophilic granulocytes has a determining impact on the intensity and duration of neutrophil driven lung inflammation. Based on the compatible solute ectoine, we aimed to prevent anti-apoptotic reactions in neutrophils triggered by the inflammatory microenvironment in
M.D. Vangala et al.
Bioforum, 23, 760-760 (2000)
Jens Smiatek et al.
Biophysical chemistry, 160(1), 62-68 (2011-10-22)
We have performed Molecular Dynamics simulations of ectoine, hydroxyectoine and urea in explicit solvent. Special attention has been spent on the local surrounding structure of water molecules. Our results indicate that ectoine and hydroxyectoine are able to accumulate more water

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