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重要文件

571024

Sigma-Aldrich

氯磺酸

99%

同義詞:

Sulfuric chlorohydrin

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About This Item

線性公式:
ClSO3H
CAS號碼:
分子量::
116.52
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.21
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蒸汽密度

4 (vs air)

品質等級

蒸汽壓力

1 mmHg ( 25 °C)
3.3 mmHg ( 37.7 °C)

化驗

99%

expl. lim.

37.7 %

折射率

n20/D 1.433 (lit.)

bp

151-152 °C/755 mmHg (lit.)

溶解度

acetic acid: soluble(lit.)
chloroform: soluble(lit.)
dichloromethane: soluble(lit.)

密度

1.753 g/mL at 25 °C (lit.)

SMILES 字串

OS(Cl)(=O)=O

InChI

1S/ClHO3S/c1-5(2,3)4/h(H,2,3,4)

InChI 密鑰

XTHPWXDJESJLNJ-UHFFFAOYSA-N

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一般說明

氯磺酸是由三氧化硫和干燥氯化氢气体以等摩尔比反应,工业规模合成一种强酸。它可以作为一种磺化、[1]脱水、氧化和氯化剂。据报道,与其他磺酸相比,它是更好的亲电子烯烃环化剂。[2]其固态、液态和气态红外光谱记录在 4000-400cm-1 范围内。[3]

應用

氯磺酸可用于以下过程:
  • 氯化磺酸二--丁酯的合成,一种仲胺离子液体。[4]
  • 制备具有增强亲水性的磺化聚醚砜(SPES)。[1]
  • 将硫酸酯基团连接到丝素蛋白上以提高其抗凝血能力。[5]
  • 作为制备取代香豆素的催化剂,通过 von Pechmann 在苯酚和 β-酮酯之间缩合。[6]
  • 作为 Biginelli 反应中酸催化剂的替代品,制备 3,4-二氢嘧啶。[7]

象形圖

Skull and crossbonesCorrosion

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 1 Inhalation - Eye Dam. 1 - Skin Corr. 1A - STOT SE 3

標靶器官

Respiratory system

安全危害

儲存類別代碼

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


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分析證明 (COA)

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Infrared spectra of methane-, fluoro-, and chlorosulfonic acids.
Chackalackal SM and Stafford FE.
Journal of the American Chemical Society, 88(21), 4815-4819 (1966)
Chlorosulfonic acid as a convenient electrophilic olefin cyclization agent.
Linares-Palomino PJ, et al.
Tetrahedron Letters, 44(35), 6651-6655 (2003)
Chlorosulfonic acid catalyzed highly efficient solvent-free synthesis of 3,4-Dihydropyrimidin-2(1H)-one and thiones.
Kotharkar SA, et al.
Ukrainica Bioorganica Acta, 2, 17-21 (2006)
Chlorosulfonic acid-catalysed one-pot synthesis of coumarin.
Kotharkar SA, et al.
Mendeleev Communications, 16(4), 241-242 (2006)
Di-n-butyl ammonium chlorosulfonate as a highly efficient and recyclable ionic liquid for the synthesis of N-containing bisphosphonates.
Reddy MV, et al.
Catalysis Communications, 61, 102-106 (2015)

Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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