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重要文件

45661

Supelco

番木鳖碱

PESTANAL®, analytical standard

同義詞:

(-)-番木鳖碱

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About This Item

經驗公式(希爾表示法):
C21H22N2O2
CAS號碼:
分子量::
334.41
Beilstein:
52979
EC號碼:
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
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等級

analytical standard

品質等級

產品線

PESTANAL®

儲存期限

limited shelf life, expiry date on the label

技術

HPLC: suitable
gas chromatography (GC): suitable

mp

284-286 °C (lit.)

應用

agriculture
cleaning products
cosmetics
environmental
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)

形式

neat

SMILES 字串

[H][C@@]12CC(=O)N3c4ccccc4[C@]56CC[N@H]7CC(=CCO1)[C@]([H])(C[C@@H]57)[C@]2([H])[C@]36[H]

InChI

1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1

InChI 密鑰

QMGVPVSNSZLJIA-FVWCLLPLSA-N

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一般說明

Strychnine is an alkaloid, available as a bioactive component in Semen Strychni, exhibiting analgesic, anti-inflammatory and anti-tumor effects.[1] It is widely used in neurological research, treatment of genetic disorder nonketotic hyperglycinemia, treatment of stomach ailments, etc.[2]

應用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Strychnine may be used as an analytical reference standard for the quantification of the analyte in biological samples using liquid chromatography coupled to electrospray ionization mass spectrometry.[1][3]

生化/生理作用

惊厥剂;与 NMDA 受体无关的甘氨酸受体拮抗剂。

法律資訊

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

象形圖

Skull and crossbonesEnvironment

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 1 Dermal - Acute Tox. 1 Oral - Aquatic Acute 1 - Aquatic Chronic 1

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 2

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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存取文件庫

Application of solid phase microextraction to the determination of strychnine in blood
Borroso.M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 816(1-2), 29-34 (2005)
The 100 Most Important Chemical Compounds: A Reference Guide (2005)
Determination of strychnine and brucine in rat plasma using liquid chromatography electrospray ionization mass spectrometry
Xu Y, et al.
Journal of Pharmaceutical and Biomedical Analysis, 49(2), 487-491 (2009)
Sébastien Dutertre et al.
The Journal of biological chemistry, 287(48), 40216-40223 (2012-10-06)
Strychnine-sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brainstem, and other regions of the mammalian central nervous system. In this minireview, we summarize our current view of the structure, ligand-binding sites, and chloride channel of these receptors
Yan Lu et al.
The Journal of clinical investigation, 123(9), 4050-4062 (2013-08-28)
Neuropathic pain is characterized by mechanical allodynia induced by low-threshold myelinated Aβ-fiber activation. The original gate theory of pain proposes that inhibitory interneurons in the lamina II of the spinal dorsal horn (DH) act as "gate control" units for preventing

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