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重要文件

17849

Sigma-Aldrich

恩诺沙星

≥99.0%

同義詞:

恩诺沙星

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About This Item

經驗公式(希爾表示法):
C19H22FN3O3
CAS號碼:
分子量::
359.39
Beilstein:
5307824
MDL號碼:
分類程式碼代碼:
41116105
PubChem物質ID:
NACRES:
NA.21
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品質等級

化驗

≥99.0%
99.0-101.0% (dried substance)

形狀

powder or crystals

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

DNA synthesis | interferes
enzyme | inhibits

SMILES 字串

CCN1CCN(CC1)c2cc3N(C=C(C(O)=O)C(=O)c3cc2F)C4CC4

InChI

1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26)

InChI 密鑰

SPFYMRJSYKOXGV-UHFFFAOYSA-N

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一般說明

化学结构式:氟喹诺酮类
恩诺沙星是一种具有广谱抗菌活性的兽用氟喹诺酮 (FQ) 类抗生素。FQ 药物以高亲和力螯合铁。这种螯合作用导致 Fe (II) 依赖性双加氧酶的抑制,这些双加氧酶参与调节表观遗传控制、胶原成熟和 HIF(缺氧诱导因子)降解。与 FQ 药物相关的副作用为肾毒性和肌腱病变。恩诺沙星用于水产养殖,它的使用可能会引起水环境中抗生素耐药微生物的增长。该药可能对公众健康和环境产生负面影响。[1][2][3]

應用

恩诺沙星曾用于:
  • 研究氟喹诺酮类药物对哺乳动物细胞毒性的病理机制[1]
  • 利用表面增强拉曼光谱 (SERS) 分析水产养殖中使用的非法鱼药[2]
  • 作为化学发光试剂系统中的分析物[4]

象形圖

Health hazardExclamation mark

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Yanina N Martínez et al.
Bioresource technology, 145, 280-284 (2013-04-06)
A keratinase isolated from Paecilomyces lilacinus (LPS #876) was tested against proteins present in the skin but the high enzyme activity was detected on collagen. Keratinase was physically immobilized onto PVA-pectin cryogels and enzyme release was 20.8±2.1%, 63.8±0.2%, 41.5±3.5% and
Jessica M Terry et al.
The Analyst, 136(5), 913-919 (2010-12-04)
Constructing flow-through reactors for chemiluminescence detection by machining channels into polymer disks has enabled the exploration of new configurations and materials that can improve signal intensity beyond that attainable with the traditional coiled-tubing design. Several approaches to merge reactant solutions
Geaneth Pertunia Mashile et al.
Polymers, 12(5) (2020-05-16)
The application of a magnetic mesoporous carbon/β-cyclodextrin-chitosan (MMPC/Cyc-Chit) nanocomposite for the adsorptive removal of danofloxacin (DANO), enrofloxacin (ENRO) and levofloxacin (LEVO) from aqueous and environmental samples is reported in this study. The morphology and surface characteristics of the magnetic nanocomposite
Sook Mei Khor et al.
Analytical and bioanalytical chemistry, 405(11), 3889-3898 (2013-02-27)
A displacement immunoassay involves having a labelled analogue of the analyte (the epitope) already bound to the antibody. The presence of the analyte causes a competition for antibodies, and some of the antibodies dissociates from the epitope so that it
Kristine H Wammer et al.
Water research, 47(1), 439-448 (2012-11-13)
Fluoroquinolone (FQ) antibacterial compounds are frequently detected in the aquatic environment, and photodegradation is expected to play an important role in FQ fate in some sunlit surface waters. This study investigated the direct aquatic photochemistry of three FQs: norfloxacin, ofloxacin

Questions

1–2 of 2 Questions  
  1. Is it possible to store the drug frozen for long-term preservation after dissolving it in organic solvents?

    1 answer
    1. The solution stability has not been tested. However, literature research suggests that enrofloxacin solutions dissolved in organic solvents such as methanol, ethanol, and dimethyl sulfoxide (DMSO) stored under frozen conditions can typically remain stable for approximately 26 to 52 weeks (6 to 12 months). The exact stability can depend on factors such as concentration, formulation, and specific storage conditions.

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  2. What is the solubility of Antibiotic Question 17849 in water? This is intended for use in a mouse experiment involving drinking water.

    1 answer
    1. The substance is not soluble in water. It has a solubility of 1mg/ml in organic solvents such as DMSO and 10 mg/ml in DMF. Additionally, it is suggested to try if the drug dissolves in (2-Hydroxypropyl)-β-cyclodextrin solution H5784.

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