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Merck
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文件

B5150

Sigma-Aldrich

杆菌肽 锌盐

from Bacillus licheniformis, ~70,000 U/g

同義詞:

杆菌肽锌

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About This Item

經驗公式（希爾表示法）:
C66H101N17O16SZn
CAS號碼:
1405-89-6
分子量：:
1486.07
EC號碼:
215-787-8
MDL號碼:
MFCD00130598
分類程式碼代碼:
51282002
PubChem物質ID:
57653938
NACRES:
NA.85

生物源

Bacillus licheniformis

形狀

powder

比活性

~70,000 U/g

mp

250 °C (dec.) (lit.)

抗生素活性譜

Gram-positive bacteria

作用方式

cell wall synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

[Zn++].CCC(C)C(N)C1=NCC(S1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC([O-])=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H]2CCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CC([O-])=O)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](Cc4ccccc4)NC(=O)[C@@H](NC(=O)[C@@H](CCCN)NC2=O)[C@@H](C)CC

InChI

1S/C66H103N17O16S.Zn/c1-9-35(6)52(69)66-72-32-48(100-66)63(97)80-43(26-34(4)5)59(93)75-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)76-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-73-39)77-60(94)44(27-38-18-13-12-14-19-38)81-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)74-56(40)90;/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,73)(H,71,89)(H,74,90)(H,75,93)(H,76,98)(H,77,94)(H,78,96)(H,79,95)(H,80,97)(H,81,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88);/q;+2/p-2/t35?,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48?,52?,53-,54-;/m0./s1

InChI 密鑰

NKULICGUDKGGRL-FCHFGNCGSA-L

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一般說明

Chemical structure: peptide

應用

Bacitracin zinc salt is a peptide antibiotic used to study dysruption of bacterial cell wall synthesis at the level of peptidoglycan biosynthesis and isoprenyl metabolism. It is used to study the biosynthesis of sterols and squalene.

生化／生理作用

Bacitracin is a protease inhibitor. Antimicrobial spectrum: Gram-positive bacteria.
Mode of Action: Inhibits bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate.

其他說明

Keep container tightly closed in a dry and well-ventilated place.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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Bacitracin: an inhibitor of the dephosphorylation of lipid pyrophosphate, an intermediate in the biosynthesis of the peptidoglycan of bacterial cell walls.
G Siewert et al.
Proceedings of the National Academy of Sciences of the United States of America, 57(3), 767-773 (1967-03-01)
Tritium--hydrogen exchange of bacitracin A. Evidence for an intramolecular hydrogen bond.
R E Galardy et al.
Biochemistry, 10(13), 2429-2436 (1971-06-22)
Mechanism of bacitracin action: a specific lipid-peptide interaction.
D R Storm
Annals of the New York Academy of Sciences, 235(0), 387-398 (1974-05-10)
T M Fong et al.
The Journal of biological chemistry, 269(4), 2728-2732 (1994-01-28)
Previous studies suggested that the antagonist binding site in the neurokinin-1 receptor is composed of phylogenetically conserved residues, while phylogenetically divergent residues affect the conformation of the binding site. To test this hypothesis, we investigated the role of conserved residues
M Ammar Zafar et al.
mBio, 10(3) (2019-06-20)
Host-to-host transmission is a necessary but poorly understood aspect of microbial pathogenesis. Herein, we screened a genomic library of mutants of the leading respiratory pathogen Streptococcus pneumoniae generated by mariner transposon mutagenesis (Tn-Seq) to identify genes contributing to its exit
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