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MABN68

Sigma-Aldrich

抗-PSD95抗体,克隆K28/43

clone K28/43, from mouse

同義詞:

Postsynaptic density protein 95, Synapse-associated protein 90, Tax interaction protein 15, discs large homolog 4, discs, large homolog 4 (Drosophila), post-synaptic density protein 95

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

mouse

品質等級

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

K28/43, monoclonal

物種活性

rat

物種活性(以同源性預測)

mouse (based on 100% sequence homology), human (immunogen homology)

技術

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

同型

IgG2aκ

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... DLG4(1742)

一般說明

PSD95(突触后致密体95)代表一类锚定蛋白,其用于将各种神经元离子通道定位于突触后致密体。PSD95和相关蛋白包含PDZ域,该域通过受体通道胞质羧基末端的ET/SXV基序与NMDA受体和电压门控K+通道相互作用。

免疫原

对应于人PSD95的重组蛋白。

應用

使用经验证可用于IH、WB&IC的抗PSD95抗体(克隆K28/43)检测PSD95。
免疫组织化学分析: 一个先前批次以1:500稀释度在大鼠皮层组织中检测到PSD95。

免疫细胞化学分析:一个先前批次已被独立实验室用于IC。(Maeda,T.,et al.(2005).Invest. Ophthalmol.Vis. Sci. 46(11):4320-4327.)
研究子类别
神经递质&受体
研究类别
神经科学

品質

通过蛋白质印迹法在大鼠脑组织裂解物中进行评估。

蛋白质印迹分析:0.5 µg/mL的该抗体在10 µg大鼠脑组织裂解物中检测到PSD95。

標靶描述

观测分子量〜95 kDa。

聯結

替代:04-1066

外觀

形式:纯化
纯化的小鼠单克隆IgG2aκ,溶于含0.1 M Tris-甘氨酸(pH 7.4)、150 mM NaCl和0.05%叠氮化钠的缓冲液中。
纯化蛋白G

儲存和穩定性

自接收之日起,在2-8°C下可稳定保存1年。

分析報告

对照
大鼠脑组织裂解物

其他說明

浓度:关于批次特定浓度请参见检验报告。

免責聲明

除非我们的目录或产品随附的其他公司文件中另有说明,否则我们的产品预期仅用于研究用途,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

Lu Yang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(48), 10846-10857 (2004-12-03)
The specification and organization of glutamatergic synaptic transmission require the coordinated interaction among glutamate receptors and their synaptic adaptor proteins closely assembled in the postsynaptic density (PSD). Here we investigated the interaction between NMDA receptors and metabotropic glutamate receptor 5
Vibeke M Bruinenberg et al.
Nutrients, 8(4), 185-185 (2016-04-23)
The inherited metabolic disease phenylketonuria (PKU) is characterized by increased concentrations of phenylalanine in the blood and brain, and as a consequence neurotransmitter metabolism, white matter, and synapse functioning are affected. A specific nutrient combination (SNC) has been shown to
Maria Eriksson et al.
Biochemical and biophysical research communications, 361(1), 127-132 (2007-07-31)
When screening a brain cDNA library, we found that the N-methyl-D-aspartate receptor subunit NR3A binds to microtubule-associated protein (MAP) 1S/chromosome 19 open reading frame 5 (C19ORF5). The interaction was confirmed in vitro and in vivo, and binding of MAP1S was
Keisuke Handa et al.
Journal of virology, 81(3), 1379-1389 (2006-11-24)
In most cervical cancers, DNAs of high-risk mucosotropic human papillomaviruses (HPVs), such as types 16 and 18, are maintained so as to express two viral proteins, E6 and E7, suggesting that they play important roles in carcinogenesis. The carboxy-terminal PDZ
Natalie Y Barnes et al.
Journal of neurochemistry, 104(6), 1637-1648 (2007-11-13)
Mutations in the genes encoding presenilins (PS1 and PS2) account for the majority of cases of early-onset Alzheimer's disease. PS1 and PS2 form the catalytic center of gamma-secretase, an enzyme responsible for intramembraneous proteolysis of several type I transmembrane proteins.

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