As you can see in the example image, this just stains every nucleus. That's not what you expect in liver, and that's not what you expect in pretty much any tissue. Not sure why we bought this one, but we definitely won't be buying it again.
MABF81
抗-ROR γT抗体，克隆6F3.1
Anti-ROR gamma T Antibody, clone 6F3.1
clone 6F3.1, from mouse
同義詞:
Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, Retinoid-related orphan receptor-gamma
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About This Item
分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
暫時無法取得訂價和供貨情況
推薦產品
生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
6F3.1, monoclonal
物種活性
human
技術
immunohistochemistry: suitable
western blot: suitable
同型
IgG2aκ
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... RORC (6097)
一般說明
类视黄醇相关的孤儿受体-γ t(RORγT)是属于核激素受体家族的两种RORγ亚型之一，并包含单个核受体DNA结合结构域。RORγT是TNFDF6/FasL表达和IL2的T细胞产生的负调节剂。RORγT的上调是TH17细胞分化的要求。TGF-β’s与Foxp3的相互作用诱导了RORγT的抑制。主要在未成熟的胸腺细胞中观察到表达，并且在胎儿发育过程中，仅在淋巴诱导（LTi）细胞中发现表达。
免疫原
GST标记的重组蛋白，对应于人RORγt。
應用
免疫组织化学分析：该抗体以1:50稀释度在正常人肝组织中检测到RORγT。
研究子类别
炎症 & 自身免疫机制
炎症 & 自身免疫机制
研究类别
炎症 & 免疫学
炎症 & 免疫学
经验证，该抗RORγT抗体（克隆6F3.1）可用于WB、IH中检测RORγT。
品質
通过蛋白质印迹法在T47D细胞裂解物中进行评估。
蛋白质印迹分析：1 µg/mL的该抗体在10 µg的T47D细胞裂解物中检测到RORγT。
蛋白质印迹分析：1 µg/mL的该抗体在10 µg的T47D细胞裂解物中检测到RORγT。
標靶描述
观测分子量〜55 kDa。在一些细胞裂解物中可观察到~55 kDa和~58 kDa的两种亚型。
外觀
形式：纯化
纯化的小鼠单克隆IgG2aκ，溶于含0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。
纯化蛋白G
儲存和穩定性
自接收之日起，在2-8°C下可稳定保存1年。
分析報告
对照
T47D细胞裂解物
T47D细胞裂解物
其他說明
浓度：关于批次特定浓度请参见检验报告。
免責聲明
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Tae Gyu Oh et al.
EBioMedicine, 6, 59-72 (2016-05-24)
We have previously reported that RORγ expression was decreased in ER-ve breast cancer, and increased expression improves clinical outcomes. However, the underlying RORγ dependent mechanisms that repress breast carcinogenesis have not been elucidated. Here we report that RORγ negatively regulates
Atsuyo Ikeda et al.
Cancer immunology research, 8(6), 724-731 (2020-04-02)
Innate lymphoid cells (ILC) are responsible for mucosal tissue homeostasis and are involved in the progression and suppression of several types of cancer. However, the effects of ILCs on colorectal cancer are poorly understood. We characterized human ILCs in normal
Hiroki Kanno et al.
Cancer science, 111(8), 3032-3044 (2020-05-26)
Tumor location and immunity play important roles in the progression of colorectal cancer (CRC). This study aimed to investigate the differences in the immunosurveillance pattern between right- and left-sided CRC and analyze their association with clinicopathologic features, including mismatch repair
Aoi Okubo et al.
International journal of molecular sciences, 23(1) (2022-01-12)
Th17 cells play an important role in psoriasis. The differentiation of naïve CD4+ T cells into Th17 cells depends on glycolysis as the energy source. CD147/basigin, an integral transmembrane protein belonging to the immunoglobulin superfamily, regulates glycolysis in association with
Huai-Chia Chuang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(10), 11469-11480 (2019-07-19)
The cytokine IL-17A plays critical roles in the pathogenesis of autoimmune diseases. The frequencies of MAP kinase kinase kinase kinase 3 [also named germinal center kinase-like kinase (GLK)]-overexpressing T cells are correlated with disease severity of systemic lupus erythematosus (SLE).
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