MAB3731

Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877

clone 6AT1877, Chemicon^®, from mouse

• 同義詞: c-Met, cmet, HGFR, RCCP2, met proto-oncogene (hepatocyte growth factor receptor)
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 6AT1877, monoclonal
• 物種活性: human, mouse
• 製造商／商標名: Chemicon^®
• 技術: ELISA: suitable
• 同型: IgG1
• NCBI登錄號: NM_000245.2
• UniProt登錄號: P08581
• 運輸包裝: wet ice
• 目標翻譯後修改: phosphorylation (pTyr1234/pTyr1235)
• 基因資訊: human ... MET(4233) ; mouse ... Met(17295)

描述

特異性

Reacts with Met/HGFR (Hepatocyte growth factor receptor) only when phosphorylated at Tyr1234 and Tyr1235. The Met receptor tyrosine kinase is the prototypical member of a small subfamily of growth factor receptors that when activated, induces mitogenic, motogenic, and morphogenic cellular responses. The ligand for Met is hepatocyte growth factor/scatter factor (HGF/SF) and while normal HGF/SF-Met signaling is required for embryonic development, abnormal Met signaling has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes.

免疫原

Epitope: phospho-specific (Tyr1234/1235)

Synthetic phospho-peptide corresponding to residues surrounding Tyr1234/1235 of human Met.

應用

Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877 detects level of Met/HGFR & has been published & validated for use in ELISA.

ELISA (direct): 1:1,000

Optimal working dilutions must be determined by the end user.

Research Category
Signaling

Research Sub Category
Growth Factors & Receptors

外觀

Format: Purified

Protein G purified immunoglobulin. Liquid in PBS containing 0.09% sodium azide.

儲存和穩定性

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container′s cap.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律資訊

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable