ABS551

Anti-Glucagon receptor Antibody

from rabbit, purified by affinity chromatography

• 同義詞: GL-R, Glucagon receptor
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human
• 物種活性（以同源性預測）: primate (based on 100% sequence homology)
• 技術: immunohistochemistry: suitable (paraffin); western blot: suitable
• NCBI登錄號: NP_000151
• UniProt登錄號: P47871
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... GCGR(2642)

描述

一般說明

Glucagon receptor or GL-R (UniProt P47871) is encoded by the GCGR (also known as GGR) gene (Gene ID 2642) in human. Glucagon is a 29-amino acid peptide that stimulates glycogenolysis and gluconeogenesis in the liver to increase blood glucose. The receptor for glucagon is a class 2 (or class B) G protein-coupled receptor (GPCR) that signals through Gs to stimulate cAMP production. Mice lacking the glucagon receptor have mild hypoglycemia after fasting and exhibit hyperplasia of pancreatic alpha-cells. Because of its role in promoting hyperglycemia, the glucagon receptor presents a potential target for treatment of diabetes.

免疫原

Epitope: Fourth cytoplasmic domain

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Glucagon receptor.

應用

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Glucagon receptor in human pancreas.

This Anti-Glucagon receptor Antibody is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Glucagon receptor.

品質

Evaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected Glucagon receptor in 10 µg of human liver tissue lysate.

標靶描述

~59 kDa observed. Target band appears larger than the calculated molecular weight of 54.0 kDa (Preform) and 51.3 kDa (mature) due to glycosylation. Lower molecular weight degradation band(s) can also be seen (Iwanij, V., et al. (1990). J. Biol Chem. 265(34):21302-21308).

其他說明

Concentration: Please refer to lot specific datasheet.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable