05-797R
抗-磷酸化-Erk1/2（Thr202/Tyr204，Thr185/Tyr187）抗体，重组克隆AW39R，兔单克隆
clone AW39R, Upstate®, from rabbit
同義詞:
Erk1, Erk2, p44-MAPK, p42-MAPK, MAPK2, PRKM2, p41mapk, PRKM1, p44, ERK2, P42MAPK, ERK, p42, MAPK1, ERT1, ERT2, Mitogen-activated protein kinase, MAP Kinase 2, MAP Kianse 1, MAPK
登入查看組織和合約定價
全部照片(1)
About This Item
分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
推薦產品
生物源
rabbit
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
AW39R, monoclonal
物種活性
human, mouse, rat
製造商／商標名
Upstate®
技術
multiplexing: suitable
western blot: suitable
同型
IgG
運輸包裝
dry ice
目標翻譯後修改
phosphorylation ((pThr202/pTyr204), (pThr185/pTyr187))
基因資訊
human ... MAPK3(5595)
mouse ... Mapk3(26417)
rat ... Mapk3(50689)
一般說明
Erk（细胞外信号相关激酶）是两个高度同源的蛋白质家族，分别称为Erk1（p44，MAPK3）和Erk2（p42，MAPK1），它们都在同一途径中起作用。 这两种蛋白通常统称为Erk1/2或p44/p42 MAP激酶。Erk途径被认为是经典的，经典的MAPK（促分裂原活化蛋白激酶）信号传导途径。它是一种进化上保守的途径，通过促进细胞增殖和防止细胞凋亡来控制并作为关键调节剂来控制生长和存活。Erk参与许多基本细胞过程的控制，包括细胞增殖，存活，分化，凋亡，运动性和代谢。Erk通过受体酪氨酸激酶（RTK）的生长因子刺激，GPCR和/或整联蛋白刺激而激活。这会激活Ras-Raf-MEK-Erk途径，从而导致TxY基序上的Erk1/2（p44/p42）磷酸化/激活（Erk1 & Erk2分别为Thr202/Tyr204和Thr185/Tyr187）。
特異性
仅当Erk 1 & 2在其TxY激活基序上双重磷酸化时才能识别Erk 1 2。
免疫原
一种磷酸化肽，对应于人磷酸化-ERK1/2激活环中pTEpY基序周围的氨基酸，其中Thr和Tyr残基被磷酸化
表位：激活环中的pTEpY
應用
抗磷酸化Erk1/2（Thr202/Tyr204抗体，Thr185/Tyr187），重组克隆AW39R检测磷酸化Erk1/2的水平（Thr202/Tyr204&已发表，&经验证可用于Mplex & WB。
研究子类别
MAP激酶
激酶&磷酸酶
MAP激酶
激酶&磷酸酶
研究类别
信号传导
信号传导
品質
已通过免疫印迹对PDGF处理的NIH/3T3细胞裂解液进行常规评估
標靶描述
Erk1 (p44) (~44 kDa) 和Erk2 (p42) (~42 kDa)。
聯結
替代：05-797
外觀
形式：纯化
蛋白A纯化
蛋白A纯化的免疫球蛋白溶于30％甘油，0.07M Tris-甘氨酸（pH 7.4）、0.105 M NaCl，0.035％叠氮化钠作为防腐剂的溶液中。
儲存和穩定性
自收到之日起在-20°C可稳定保存1年。处理建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于 -20°C。避免反复冻融循环，以免损坏 IgG 和影响产品性能。
分析報告
对照
PDGF处理的NIH/3T3细胞裂解液
PDGF处理的NIH/3T3细胞裂解液
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Not finding the right product?
Try our 產品選擇工具.
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Dhia Azzouz et al.
Cell death discovery, 4, 51-51 (2018-05-08)
NETosis is a unique form of neutrophil death that differs from apoptosis and necrosis. However, whether NETosis and apoptosis can occur simultaneously in the same neutrophil is unknown. In this paper, we show that increasing doses of ultraviolet (UV) irradiation
Crescent R Isham et al.
The Journal of clinical endocrinology and metabolism, 99(6), E936-E943 (2014-03-19)
Vascular endothelial growth factor-targeted kinase inhibitors have emerged as highly promising therapies for radioiodine-refractory metastatic differentiated thyroid cancer. Unfortunately, drug resistance uniformly develops, limiting their therapeutic efficacies and thereby constituting a major clinical problem. To study acquired drug resistance and
Wen-Tsan Chang et al.
Molecules (Basel, Switzerland), 22(5) (2017-05-23)
Hepatocellular carcinoma (HCC) is a leading cancer worldwide. Advanced HCCs are usually resistant to anticancer drugs, causing unsatisfactory chemotherapy outcomes. In this study, we showed that a 4-phenoxyphenol derivative, 4-[4-(4-hydroxyphenoxy)phenoxy]phenol (4-HPPP), exerts an inhibitory activity against two HCC cell lines
Jiamin Cheng et al.
Oncotarget, 7(15), 20597-20611 (2016-03-12)
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death. This high mortality has been commonly attributed to the presence of residual cancer stem cells (CSCs). Meanwhile, MEK1 signaling is regarded as a key molecular in HCC maintenance and
Chun-Hsu Pan et al.
Aging, 11(19), 8085-8102 (2019-10-05)
The relationship between aging and restenosis are unclear. The purposes of this study were to investigate the possible pathological role and mechanism of aging on formation of restenosis. Our data indicated that cell proliferation and migration of the oxidative stress-induced
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務