ABN433

Anti-Corticotropin-Releasing Factor Receptor 2 Antibody

1.0 mg/mL, from rabbit

• 同義詞: Corticotropin-releasing factor receptor 2, CRF-R-2, CRF-R2, CRFR-2, Corticotropin-Releasing Factor Receptor 2, Corticotropin-releasing hormone receptor 2, CRH-R-2, CRH-R2
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• 無性繁殖: polyclonal
• application: IHC; WB
• 物種活性: human
• 技術: immunohistochemistry: suitable; western blot: suitable
• citations: 1

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human
• 物種活性（以同源性預測）: monkey (based on 100% sequence homology), mouse (based on 100% sequence homology), rat (based on 100% sequence homology), hamster (based on 100% sequence homology), primate (based on 100% sequence homology)
• 濃度: 1.0 mg/mL
• 技術: immunohistochemistry: suitable; western blot: suitable
• NCBI登錄號: NP_001189404
• UniProt登錄號: Q13324
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... CRHR2(1395)

描述

一般說明

Corticotropin-Releasing Factor Receptor 2 (CRFR2) is a G-protein coupled receptor for CRH (Corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Ligand binding activates adenylate cyclase leading to an increase in cAMP levels and subsequent gene activation. CRFR2 binds Urocortin (UCN) with the highest affinity. CRFR2 is localized to the plasma membrane, and CRFR2 has numerous isoforms but their functional importance remains to be discovered. Latest research is focused upon antagonists of the receptors for CRF. Astressin2-B, which is specific for CRFR2 and Astressin B which binds both CRFR1 and CRFR2 are two recent peptide antagonists. The research hopes to develop treatments for many CRF-dependent diseases in the periphery such as irritable bowel syndrome and even perhaps various social behaviors such as anxiety and anti-social activities.

免疫原

Epitope: Near N-terminal

KLH-conjugated linear peptide corresponding to human Corticotropin-Releasing Factor Receptor 2 near the N-terminal.

應用

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

This Anti-Corticotropin-Releasing Factor Receptor 2 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of Corticotropin-Releasing Factor Receptor 2.

Western Blotting Analysis: 1.0 µg/mL from a representative lot detected Corticotropin-Releasing Factor Receptor 2 in 10 µg of human brain tissue lysate.
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Corticotropin-Releasing Factor Receptor 2 in human colon and Bowman′s capsule epithelial cells.

品質

Evaluated by Western Blotting in human colon tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Corticotropin-Releasing Factor Receptor 2 in 10 µg of human colon tissue lysate.

標靶描述

~49 kDa observed. Uniprot describes 5 isoforms produced by alternative splicing from ~45-65 kDa

聯結

Replaces: AB9420

外觀

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable