Twist1 是碱性螺旋-环-螺旋转录因子,可调节胚胎祖细胞和转化的肿瘤细胞的增殖、迁移和分化,并且在肢体发育中也很重要。研究表明,twist1 在患有具有慢性活化的 T 辅助淋巴细胞的风湿性炎性疾病的患者中高表达,并且可以用作慢性 t 细胞活化的生物标志物。twist1 突变通常与 Saethre-Chotzen 综合征患者的颅面骨畸形和肢体畸形有关。Twist1 二聚体亲和力可以修饰 DNA 结合亲和力。Twist1 也被认为促进肿瘤生长、侵袭和抗癌药耐药性。
特異性
其他同源性: 大鼠(92% 序列同源性)。
该抗体在 N 端附近识别 Twist1。
免疫原
对应于人 Twist1 的 N 端附近的 KLH 偶联的线性肽。
表位:N 端附近
應用
使用经过验证可用于 IH(P)& IC 的抗 Twist1(Twist 相关蛋白 1)抗体检测 Twist1(Twist 相关蛋白 1)。
免疫细胞化学分析: 一个代表性批次以 1:500 的稀释度在 NIH/3T3、A431 和 HeLa 细胞中检测到 Twist1。
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