推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
顏色
white to slightly yellow
溶解度
water: 10 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
SMILES 字串
[Na+].[O-]C(=O)CCCc1ccccc1
InChI
1S/C10H12O2.Na/c11-10(12)8-4-7-9-5-2-1-3-6-9;/h1-3,5-6H,4,7-8H2,(H,11,12);/q;+1/p-1
InChI 密鑰
VPZRWNZGLKXFOE-UHFFFAOYSA-M
一般說明
一种抗肿瘤药物，在多种造血和实体瘤细胞系中表现出强大的分化能力。作为肿瘤细胞抑制和分化以及过氧化物酶体增殖的诱导剂。一种比其结构类似物（包括2-和3-苯基丁酸）更有效的组蛋白去乙酰化酶抑制剂和组蛋白乙酰化诱导剂。作为转录调节剂，通过减少上皮细胞中HSC70的表达，提高δF508-CFTR（囊性纤维化跨膜调节器）泛素化和降解的靶向性。此外，据报道，在体外和体内增加胎儿血红蛋白的产生。
一种新型抗肿瘤药物和转录调控因子。还可作为肿瘤细胞抑制和分化的诱导剂。在体外和体内增加胎儿血红蛋白的生成。。
生化／生理作用
主靶
抗肿瘤因子
抗肿瘤因子
产物不与ATP竞争。
可逆：否
细胞可渗透性：否
警告
毒性：标准处理（A）
重構
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
其他說明
Tso, S.C., et al. 2013.Proc.Natl.Acad.Sci. USA110, 9728.
Ozcan, U., et al. 2006.Science313, 1137.
Carducci, M.A., et al. 2001.Clin. Cancer Res.7, 3047.
Rubenstein, R.C. and Zeitlin, P.L.2000.Am.J.Physiol.Cell.Physiol.278, C259.
Lea, M.A., et al. 1999.Anticancer Res.19, 1971.
Miller, A.C., et al. 1997.Int. J. Radiat.Biol. 72, 211.
Rubenstein, R.C., et al. 1997.J. Clin. Invest. 100, 2457.
Pineau, T., et al. 1996.Biochem.Pharmacol.52, 659.
Collins, A.F., et al. 1995.Blood 85, 43.
Lea, M.A., et al. 1995.Anticancer Res.15, 879.
Figg, W.D., et al. 1994.Anticancer Drugs 5, 336.
Liu, L., et al. 1994.J. Invest. Dermatol.103, 335.
Ozcan, U., et al. 2006.Science313, 1137.
Carducci, M.A., et al. 2001.Clin. Cancer Res.7, 3047.
Rubenstein, R.C. and Zeitlin, P.L.2000.Am.J.Physiol.Cell.Physiol.278, C259.
Lea, M.A., et al. 1999.Anticancer Res.19, 1971.
Miller, A.C., et al. 1997.Int. J. Radiat.Biol. 72, 211.
Rubenstein, R.C., et al. 1997.J. Clin. Invest. 100, 2457.
Pineau, T., et al. 1996.Biochem.Pharmacol.52, 659.
Collins, A.F., et al. 1995.Blood 85, 43.
Lea, M.A., et al. 1995.Anticancer Res.15, 879.
Figg, W.D., et al. 1994.Anticancer Drugs 5, 336.
Liu, L., et al. 1994.J. Invest. Dermatol.103, 335.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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