559393-M

SB 202190, Hydrochloride

A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190.

• 同義詞: SB 202190, Hydrochloride, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor II, Hydrochloride
• 經驗公式（希爾表示法）: C₂₀H₁₄FN₃O · xHCl
• CAS號碼: 350228-36-3
• 分子量：: 331.34 (free base basis)
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥97% (HPLC)
• 形狀: solid
• 效力: 16 nM K_i
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 顏色: amber
• 溶解度: water: 0.5 mg/mL (slightly soluble); DMSO: soluble
• 儲存溫度: −20°C
• InChI: 1S/C20H14FN3O.ClH/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15;/h1-12,25H,(H,23,24);1H
• InChI 密鑰: XOQSUTIMRLPFPB-UHFFFAOYSA-N

描述

一般說明

A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388).

A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388).

生化／生理作用

Target IC₅₀: 350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)

警告

Toxicity: Standard Handling (A)

重構

Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable