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Merck
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重要文件

537075

Sigma-Aldrich

(±)-Propranolol, Hydrochloride

A highly lipophilic agent that blocks both β₁ and β₂ adrenergic receptors with equal potency.

同義詞:

(±)-Propranolol, Hydrochloride, (±)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol, HCl

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About This Item

經驗公式（希爾表示法）:
C16H21NO2 · xHCl
CAS號碼:
3506-09-0
分子量：:
259.34 (free base basis)
分類程式碼代碼:
12352200
暫時無法取得訂價和供貨情況

品質等級

100

化驗

≥97% (HPLC)

形狀

powder

製造商／商標名

Calbiochem®

儲存條件

OK to freeze

顏色

white

溶解度

methanol: soluble
water: soluble

運輸包裝

ambient

儲存溫度

−20°C

InChI

1S/C17H23NO2.ClH/c1-13(2)10-18-11-15(19)12-20-17-9-5-7-14-6-3-4-8-16(14)17;/h3-9,13,15,18-19H,10-12H2,1-2H3;1H

InChI 密鑰

RTTYPFXTLKDXPS-UHFFFAOYSA-N

一般說明

A highly lipophilic agent that blocks both β1 and β2 adrenergic receptors with equal potency. Has no effect on α-adrenergic receptors. Also binds to 5HT-1B receptors with high affinity (Ki = 17 nM) in contrast to 5HT-1D receptors (Ki = 10.2 µM). Readily enters the central nervous system. Blocks phospholipase D-derived diacylglycerol (DAG) formation by inhibiting phosphatidate phosphohydrolase. Useful tool for discriminating between phospholipase D- or phospholipase C-mediated DAG production. An anti-hypertensive agent that is also used in the treatment of cardiac arrhythmias.

生化／生理作用

Cell permeable: no
Primary Target
β1 and β2 adrenergic receptors
Product does not compete with ATP.
Reversible: no
Target Ki: 17 nM for 5HT-1B receptors

警告

Toxicity: Harmful (C)

重構

Following reconstitution, aliquot and freeze (-20°C).

其他說明

Fujita, K., et al. 1996. FEBS Lett.395, 293.
Glennon, R.A., et al. 1996. Mol. Pharmacol.49, 198.
Thompson, N.T., et al. 1991. Trends Pharmacol. Sci.12, 404.
Hoffman, B.B., and Lefkowitz, R.J. 1990. in The Pharmacological Basis of Therapeutics (Gilman, A.G., et al., Eds.) p. 221, Pergamon Press, New York.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H302

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

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