5.08410

Glycogen Phosphorylase Inhibitor II, KB228

• 同義詞: Glycogen Phosphorylase Inhibitor II, KB228, KB-228
• 經驗公式（希爾表示法）: C₁₆H₂₂N₂O₇
• CAS號碼: 1595277-35-2
• 分子量：: 354.36
• MDL號碼: MFCD00000133
• 分類程式碼代碼: 51111800
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 品質等級: 100
• 形狀: powder
• 效力: 930 nM K_i
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: DMSO: 100 mg/mL
• 儲存溫度: −20°C

描述

一般說明

A glucopyranosyl urea compound that acts as an inhibitor of muscle glycogen phosphorylase (K_i = 930 nM). Displays a mixed type of inhibition. Enhances glucose sensitivity in chow-fed, obese, diabetic mice and increasing hepatic glucose uptake. Reduces blood glucose levels and increases hepatic glycogen content in C57/BL6J mice. Shown to increase mitochondrial oxidation in Hep2G cells under normoglycemic conditions. Enhances the expression of uncoupling proteins2 (UCP2) in HepG2 cells. This effect was less pronounced under hyperglycemic conditions.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

生化／生理作用

Cell permeable: yes

Primary Target
Glycogen Phosphorylase

Reversible: yes

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Nagy, L., et al. 2013. PLoS One.8, e69420.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable