The MMP Inhibitor V, also referenced under CAS 223472-31-9, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
An orally active non-peptidyl hydroxamate compound that acts as an effective broad-spectrum inhibitor against MMP-2, -3, -8, -9, -12, -13 (Ki = 0.73, 42, 1.1, 2.1, 0.45, and 1.1 nM, respectively), but not MMP-1 (IC50 = 1.6 µM), MMP-7 (Ki = 2.5 µM), or other serine proteases (no activity against chymotrypsin or plasmin at 100 µM). Widely used in studying MMP-mediated diseases development in vivo. Also reported to block P-LAP secretase activity (≥70% inhibition of P-LAP shedding at 10 µM) that is otherwise not inhibited by TIMP-1/2 in CHO cell cultures in vitro.
包裝
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
其他說明
Okamoto, Y., et al. 2007. Int. Heart J.48, 369. Ito, N., et al. 2004. Biochem. Biophys. Res. Commun.314, 1008. Shiraga, M., et al. 2002. Cancer Res.62, 5967. Mori, T., et al. 2001. Exp. Biol. Med.226, 429. Yamada, A., et al. 2000. Inflamm. Res.49, 144.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Journal of peptide science : an official publication of the European Peptide Society, 23(12), 845-854 (2017-10-24)
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Select different protease inhibitor types based on your needs to prevent protein degradation during isolation and characterization and safeguard proteins in sample prep.
