324897

eIF-2α Inhibitor, Salubrinal

InSolution, ≥95%

• 同義詞: InSolution eIF-2α Inhibitor, Salubrinal, N-(2,2,2-Tichloro-1-(3-quinolin-8-ylthioureido)ethyl)cinnamamide
• 經驗公式（希爾表示法）: C₂₁H₁₇Cl₃N₄OS
• CAS號碼: 304475-63-6
• 分子量：: 479.81
• MDL號碼: MFCD00548612
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: liquid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• SMILES 字串: S=C(NC(NC(/C=C/C1=CC=CC=C1)=O)C(Cl)(Cl)Cl)NC2=CC=CC3=C2N=CC=C3

描述

一般說明

A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC₅₀ ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC₅₀ ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo. The solid form of this compound (Cat. No. 324895) is also available.

生化／生理作用

Cell permeable: yes

Primary Target
eIF-2α

包裝

Packaged under inert gas

警告

Toxicity: Irritant (B)

外觀

A 50 mM (5 mg/208 µL) solution of eIF-2α Inhibitor, Salubrinal (Cat. No. 324895) in DMSO.

重構

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

其他說明

Boyce, M., et al. 2005. Science307, 935.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: 188.6 °F - closed cup - (refers to pure substance)
• 閃點（°C）: 87 °C - closed cup - (refers to pure substance)