There is a slight difference in the chemical structure of each compound. Cytochalasin B is a cell-permeable fungal toxin. It Inhibits cytoplasmic division by blocking the formation of contractile microfilaments, inhibits cell movement, and induces nuclear extrusion. Cytochalasin B shortens actin filaments by blocking monomer addition at the fast growing end of polymers. It also Inhibits glucose transport and platelet aggregation, blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells. Dihydrocytochalasin B (DCB) is a member of the cytochalasin mycotoxin family that inhibits actin assembly. It has an effect on cell motility and morphology similar to that of cytochalasin B. However, it does not inhibit glucose transport. The following publication may be of interest:
https://pubmed.ncbi.nlm.nih.gov/272649/
推薦產品
產品名稱
细胞松弛素B，来源于长蠕孢菌, Cell-permeable fungal toxin.
品質等級
描述
Merck USA index - 14, 2790
化驗
≥98% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
white
溶解度
methanol: 20 mg/mL
DMSO: 50 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
SMILES 字串
N1[C@H]([C@H]3[C@@]4(OC(=O)\C=C\[C@@H](CCC[C@H](C\C=C\[C@H]4[C@@H](C(=C)[C@H]3C)O)C)O)C1=O)Cc2ccccc2
InChI
1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
InChI 密鑰
GBOGMAARMMDZGR-TYHYBEHESA-N
一般說明
细胞可透过性真菌毒素。通过阻止收缩性微丝的形成来抑制细胞质分裂。抑制细胞运动并诱导核挤压。通过阻止聚合物快速生长端的单体添加来缩短肌动蛋白丝。抑制葡萄糖转运和血小板聚集。阻断腺苷诱导的凋亡小体形成，而不影响白血病HL-60细胞内源性ADP核糖基化的激活。
生化／生理作用
主要目的
阻断收缩性微丝的形成
阻断收缩性微丝的形成
产品不与ATP竞争。
可逆：否
细胞渗透性：是
注意
劣质DMSO会导致产品降解，因此建议选用高质量的DMSO。
警告
毒性：&
重構
复溶后，储存在冰箱中（4°C）。储备溶液在4°C下可稳定保存3个月。
其他說明
Tanaka, Y., et al. 1994.Exp.Cell Res. 213, 242.
Theodoropoulos, P.A., et al. 1994.生物化学。Pharmacol.47, 1875.
Benya, P.D., and Padilla, S.R.1993.Exp.Cell Res. 204, 268.
Cairns, M.T., et al. 1991.J. Biol. Chem.266, 8176.
Nowak, D. 1990.Biomed.Biochim.Acta49, 353.
Wang, F., et al. 1990.Biochem.Biophys.Res. Commun.171, 543.
Edwards, S.W., and Lloyd, D. 1988.FEBS Lett.227, 39.
Theodoropoulos, P.A., et al. 1994.生物化学。Pharmacol.47, 1875.
Benya, P.D., and Padilla, S.R.1993.Exp.Cell Res. 204, 268.
Cairns, M.T., et al. 1991.J. Biol. Chem.266, 8176.
Nowak, D. 1990.Biomed.Biochim.Acta49, 353.
Wang, F., et al. 1990.Biochem.Biophys.Res. Commun.171, 543.
Edwards, S.W., and Lloyd, D. 1988.FEBS Lett.227, 39.
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法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Danger
危險分類
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Repr. 2
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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Cytochalasin B, Helminthosporium dematioideum & other option is Dihydrocytochalasin B. What is the difference?
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