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Key Documents

SML1253

Sigma-Aldrich

CASIN

≥98% (HPLC)

同義詞:

2-[(2,3,4,9-四氢-6-苯基-1H-咔唑-1-基)氨基]乙醇, Cdc42 活动特异性抑制剂

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About This Item

經驗公式(希爾表示法):
C20H22N2O
CAS號碼:
分子量::
306.40
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

, white to very dark brown

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

OCCNC1CCCC2=C1NC3=C2C=C(C4=CC=CC=C4)C=C3

InChI

1S/C20H22N2O/c23-12-11-21-19-8-4-7-16-17-13-15(14-5-2-1-3-6-14)9-10-18(17)22-20(16)19/h1-3,5-6,9-10,13,19,21-23H,4,7-8,11-12H2

InChI 密鑰

RXIUMAOXORBRCY-UHFFFAOYSA-N

應用

CASIN 已被用作细胞分裂控制蛋白 42 同源物(Cdc42)抑制剂:
  • 研究它对肠上皮细胞胞外囊泡(EV)的刺激作用
  • 研究它对小鼠空肠的影响
  • 研究它对分节丝状细菌(SFB)定植小鼠体内微生物黏附触发的内吞作用(MATE)囊泡形态的影响

生化/生理作用

CASIN是Cdc42 GTPase的抑制剂,Cdc42 GTPase是Rho亚家族的一种小GTP酶,在细胞骨架组织、细胞周期进程、信号转导和囊泡运输中起重要作用。 CASIN产生了造血干细胞(HSC)的恢复活力的表型,将衰老的HSC的衰老相关和极性表型逆转为体内年轻的HSC 的衰老相关和极性表型

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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