217720

Cdk1/5 Inhibitor

The Cdk1/5 Inhibitor, also referenced under CAS 40254-90-8, controls the biological activity of Cdk1/5. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 同義詞: Cdk1/5 Inhibitor, 3-Amino-1H-pyrazolo[3,4-b]quinoxaline
• 經驗公式（希爾表示法）: C₉H₇N₅
• CAS號碼: 40254-90-8
• 分子量：: 185.19
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: red
• 溶解度: DMSO: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C9H7N5/c10-8-7-9(14-13-8)12-6-4-2-1-3-5(6)11-7/h1-4H,(H3,10,12,13,14)
• InChI 密鑰: DWHVZCLBMTZRQM-UHFFFAOYSA-N

描述

一般說明

A 3-amino substituted pyrazoloquinoxaline compound that acts as a selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdks; IC₅₀ = 0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively). Also shown to inhibit GSK-3β with (IC₅₀ = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC₅₀ >10 µM).

A selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdk1/Cdk5) (IC₅₀ = 600 nM for Cdk1/cyclin B and 400 nM for Cdk5/p25). Also shown to inhibit glycogen synthase kinase-3β (GSK-3β) (IC₅₀ = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC₅₀ >10 µM).

生化／生理作用

Cell permeable: no

Primary Target
Cdk1/cyclin B, Cdk5/p25

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Ortega, M.A., et al. 2002. Bioorg. Med. Chem.10, 2177.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1