203303

Bisindolylmaleimide V

A cell-permeable negative control compound for protein kinase C inhibition studies (IC₅₀ >100 µM).

• 同義詞: Bisindolylmaleimide V, 2,3- bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045, 2,3-bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045
• 經驗公式（希爾表示法）: C₂₁H₁₅N₃O₂
• CAS號碼: 113963-68-1
• 分子量：: 341.36
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: red-orange
• 溶解度: DMSO: 10 mg/mL; methanol: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C21H15N3O2/c1-24-20(25)18(14-10-22-16-8-4-2-6-12(14)16)19(21(24)26)15-11-23-17-9-5-3-7-13(15)17/h2-11,22-23H,1H3
• InChI 密鑰: SWAWYMIKGOHZMR-UHFFFAOYSA-N

描述

一般說明

A cell-permeable negative control compound for protein kinase C inhibition studies (IC₅₀ >100 µM). Blocks the activation of mitogen-stimulated protein kinase p70^s6k/p85^s6kin vivo (IC₅₀ 8 µM).

A cell-permeable negative control compound for protein kinase C inhibition studies (IC₅₀ >100 µM). Blocks the activation of p70^s6k/p85^s6kin vivo (IC₅₀ = 8 µM).

生化／生理作用

Cell permeable: yes

Primary Target
Negative control compound for protein kinase C inhibition

Product does not compete with ATP.

Reversible: no

Target IC₅₀: >100 µM as negative control compound for protein kinase C inhibition; 8 µM in blocking the activation of mitogen-stimulated protein kinase p70s6k/p85s6k in vivo

警告

Toxicity: Standard Handling (A)

其他說明

Marmy-Conus, N., et al. 2002. FEBS Lett. 26094 (In Press) 1-6.
Davis, P.D., et al. 1992. J. Med. Chem.35, 177.
Toullec, D., et al. 1991. J. Biol. Chem.266, 15771.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable