Staurosporine is soluble in ethyl acetate, DMSO at 5 mg/mL, and DMF. It is slightly soluble in chloroform and methanol at 2 mg/mL, and insoluble in water. Stock solutions should be aliquoted, purged with an inert gas, and stored at -20 °C, where they should remain stable for approximately 6 months.
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一般說明
适合用作体外和培养细胞中的 PKC 以及其他蛋白激酶的有效抑制剂。
應用
星状孢菌素已被用作蛋白激酶抑制剂，在蛋白水平上研究了泛素蛋白连接酶E3组分N-识别蛋白5 (UBR5)介导的CDC73调控。十字孢碱已被用于诱导CHO-K1细胞系的凋亡，随后进行细胞成像和细胞裂解物提取以便进一步分析。[1]
生化／生理作用
星状孢菌素是一种广谱蛋白激酶抑制剂，属于吲哚卡巴唑家族。它被称为典型的ATP竞争性激酶抑制剂。星状孢菌素对各种癌症都有效。它通常用于诱导不同类型细胞的凋亡。
品質
通过蛋白激酶抑制分析进行了常规评估
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Warning
危險聲明
危險分類
Aquatic Chronic 4 - Repr. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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What is the buffer for Staurosporine rework? At what concentration should it be resumed? Storage in aliquots at what temperature and for how long. Thank you
1 answer-
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