推薦產品
品質等級
化驗
≥90% (TLC)
形狀
solid
反應適用性
reagent type: chelator
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
light yellow
溶解度
DMSO: 10 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
SMILES 字串
N(CC(=O)OCOC(=O)C)(CC(=O)OCOC(=O)C)c1c(cccc1)OCCOc2c(cccc2)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C
InChI
1S/C34H40N2O18/c1-23(37)47-19-51-31(41)15-35(16-32(42)52-20-48-24(2)38)27-9-5-7-11-29(27)45-13-14-46-30-12-8-6-10-28(30)36(17-33(43)53-21-49-25(3)39)18-34(44)54-22-50-26(4)40/h5-12H,13-22H2,1-4H3
InChI 密鑰
YJIYWYAMZFVECX-UHFFFAOYSA-N
相關類別
一般說明
BAPTA膜透过形式。可以加载到各种各样的细胞中，在其中它被胞质酯酶水解，并作为活性螯合剂BAPTA捕获在细胞内。防止可卡因引起的心室纤颤。消除维生素D3诱导的细胞内Ca2+增加。诱导蛋白激酶C失活。还抑制毒胡萝卜素诱导的大鼠胸腺细胞凋亡。
應用
- TRPV1-Dependent Antiproliferative Activity of Dioecious Maclura pomifera Extracts in Estrogen Receptor-Positive Breast Cancer Cell Lines Involves Multiple Apoptotic Pathways.：本文研究如何通过调节乳腺癌细胞中的TRPV1和凋亡通路发挥抗增殖作用，过程中用到钙螯合剂BAPTA/AM(Rumpa et al., 2024)。
- Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence.：本文体现BAPTA/AM可缓解与肾细胞衰老和肾脏老化过程有关的线粒体钙超载(Xiong et al., 2024)。
- TRPV3 facilitates lipolysis and attenuates diet-induced obesity via activation of the NRF2/FSP1 signaling axis.：本文研究TRPV3通道如何通过激活NRF2/FSP1通路增强脂解和抗肥胖保护，BAPTA/AM在通道调节实验中起作用(Hu et al., 2024)。
- Inflammation and Acinar Cell Dual-Targeting Nanomedicines for Synergistic Treatment of Acute Pancreatitis via Ca(2+) Homeostasis Regulation and Pancreas Autodigestion Inhibition.：使用BAPTA/AM调节钙稳态以抑制急性胰腺炎治疗导致的炎症和自身消化(Wang et al., 2024)。
- IP(3)R-Mediated Calcium Release Promotes Ferroptotic Death in SH-SY5Y Neuroblastoma Cells.：本文研究BAPTA/AM如何抑制IP3R介导的钙释放，从而减少神经母细胞瘤细胞铁死亡(Campos et al., 2024)。
包裝
用惰性气体包装
警告
毒性：刺激性（B）
重構
复溶后，分装，用惰性气体吹扫，然后冻存（-20°C）。储备液可在-20°C最长稳定1个月。
其他說明
Bissonnette, M., et al. 1994.Am. J. Physiol.267, G465.
Jiang, S., et al. 1994.Exp.Cell Res.212, 84.
Billman, G.E.1993.Am. J. Physiol.265, H1529.
Dieter, P., et al. 1993.Biol. Chem. Hoppe Seyler 374, 171.
Harrison, S.M., and Bers, D.M.1987.Biochim.Biophys.Acta 925, 133.
Harrison, S.M., and Bers, D.M.1987.J. Biophys.51, 102A.
Marban, E., et al. 1986.J. Clin. Invest.78, 1185.
Tsien, R.Y.1981.Nature290, 527.
Tsien, R.Y.1980.Biochemistry19, 2396.
Jiang, S., et al. 1994.Exp.Cell Res.212, 84.
Billman, G.E.1993.Am. J. Physiol.265, H1529.
Dieter, P., et al. 1993.Biol. Chem. Hoppe Seyler 374, 171.
Harrison, S.M., and Bers, D.M.1987.Biochim.Biophys.Acta 925, 133.
Harrison, S.M., and Bers, D.M.1987.J. Biophys.51, 102A.
Marban, E., et al. 1986.J. Clin. Invest.78, 1185.
Tsien, R.Y.1981.Nature290, 527.
Tsien, R.Y.1980.Biochemistry19, 2396.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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