14-787-M

PI3 Kinase (p110α (H1047R)/p85α) Murine, 10 µg

Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation H1047R α & untagged, recombinant, full length mouse p85α. For use in Kinase Assays.

• 分類程式碼代碼: 12352200
• eCl@ss: 32160405
• NACRES: NA.32

屬性

• 生物源: mouse
• 品質等級: 100; 300
• 重組細胞: expressed in baculovirus infected Sf21 cells
• 分子量: M_w 129 kDa (p110α; H1047R); M_w 83.6 kDa (p85α)
• 製造商／商標名: Upstate^®
• 技術: activity assay: suitable (kinase)
• NCBI登錄號: NM_006218.2
• UniProt登錄號: P42336
• 基因資訊: mouse ... PIK3CA(18706)

描述

一般說明

Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation H1047R αand untagged, recombinant, full length mouse p85α.

Product Source: Coexpressed by baculovirus in Sf21 insect cells.

The H1047R substitution in p110α is associated with a number of human cancers. The residue is conserved between the human and mouse sequences. In vitro studies have shown that this mutation confers increased lipid kinase activity compared to wild type, and is able to induce oncogenic transformation.

應用

Research Category
Inflammation & Immunology

生化／生理作用

Protein Target: PI3Kα/p85α

Target Sub-Family: PI3K/PI4K

包裝

Also available in 250μg size --call for pricing and availability and reference catalog number 14-787M when ordering the 250μg size.

外觀

Ni²⁺/NTA-agarose

儲存和穩定性

Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.

其他說明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H317
• 防範說明: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危險分類: Skin Sens. 1
• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable