09-872

Anti-Methylcytosine dioxygenase TET1 Antibody

from rabbit, purified by affinity chromatography

• 同義詞: tet oncogene 1, Ten-eleven translocation 1 gene protein, CXXC-type zinc finger protein 6, methylcytosine dioxygenase TET1, CXXC finger 6, ten-eleven translocation-1, Leukemia-associated protein with a CXXC domain
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: mouse
• 技術: ChIP: suitable (ChIP-seq); western blot: suitable
• NCBI登錄號: NP_081660
• UniProt登錄號: Q3URK3
• 運輸包裝: wet ice
• 基因資訊: human ... TET1(80312)

描述

一般說明

Methylcytosine dioxygenase TET1 (mTET1) is a member of the TET family and contains a characteristic CXXC-type zinc finger domain. mTET1 binds methylcytosine (5mC), a minor, mammalian DNA base necessary to development and retrotransposon silencing, and acts as a catalyst to induce the conversion of 5mC to 5-hydromethylcytosine (hmC or 5hmC), a mammalian DNA base thought to be involved in chromatin structure and in the development of fetal brain, heart and lung tissues. Recent studies indicate that mTET1 regulates the levels of 5hmC, thereby influencing patterns in DNA methylation.

特異性

Other homologies: Rat (66% sequence homology), Human (61% sequence homology).

This antibody recognizes methylcytosine dioxygenase TET1 near the C-terminus.

免疫原

Epitope: Near the C-terminus

KLH-conjugated linear peptide corresponding to mouse Methylcytosine dioxygenase TET1 near the C-terminus.

應用

Anti-Methylcytosine dioxygenase TET1 Antibody is a Rabbit Polyclonal Antibody for detection of Methylcytosine dioxygenase TET1 also known as tet oncogene 1 & has been validated in WB, ChIP-seq.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Histone Modifying Proteins

Western Blot (Snap i.d.) Analysis: 5 µg/mL from a previous lot detected Methylcytosine dioxygenase TET1 in 10 µg of mouse embryonic stem cell lysate.

品質

Evaluated by Western Blot in mouse embryonic stem cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected Methylcytosine dioxygenase TET1 in 10 µg of mouse embryonic stem cell lysate.

標靶描述

~220 kDa observed.
Uncharacterized bands may be seen at ~32, 68, and 70 kDa

外觀

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
Mouse embryonic stem cell lysate

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable