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T-074

Supelco

3,3′,5-三碘-L-甲状腺原氨酸（T3） 溶液

100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

同義詞:

3,3′,5-三碘代-L-甲状腺原氨酸, O-(4-羟基-3-碘苯基)-3,5-二碘代-L-酪氨酸, T3, 碘噻罗宁

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About This Item

經驗公式（希爾表示法）:
C15H12I3NO4
CAS號碼:
6893-02-3
分子量：:
650.97
Beilstein:
2710227
MDL號碼:
MFCD00002593
分類程式碼代碼:
41116107
PubChem物質ID:
329826618
NACRES:
NA.24
暫時無法取得訂價和供貨情況

等級

certified reference material

形狀

liquid

特點

Snap-N-Spike®/Snap-N-Shoot®

包裝

ampule of 1 mL

製造商／商標名

Cerilliant®

濃度

100 μg/mL in methanol with 0.1N NH3

技術

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

234-238 °C (lit.)

應用

clinical testing
clinical testing

形式

single component solution

儲存溫度

−20°C

SMILES 字串

N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1

InChI 密鑰

AUYYCJSJGJYCDS-LBPRGKRZSA-N

基因資訊

human ... THRA(7067) , THRB(7068)

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相關類別

一般說明

该认证加标溶液® 适合用作制备线性标准品、校准品和对照品的起始物料，用于通过 LC-MS/MS 法检测甲状腺激素。

3,3′,5-三碘-L-甲状腺原氨酸（T3）是一种甲状腺激素，也是 l -甲状腺素（T4）的活性形式，由 I 型或 II 型脱碘酶形成。它支持各种生理功能，如氧气消耗、碳水化合物代谢、蛋白质合成和神经发育。通过 LC-MS/MS 测量游离和总 T3 血清水平，以确定由过量 T3 引起的甲状腺功能亢进症。

應用

该认证标准物质（CRM）还可作如下用途：

  • 通过同位素稀释液相色谱-四极杆飞行时间质谱法（LC-Q-TOF-MS）对胎盘样品中的七种甲状腺激素进行多残留测定
  • 通过固相萃取（SPE）和超高效液相色谱-电喷雾电离-串联质谱（UPLC-ESI/MS/MS）分析斑马鱼幼体中的 5 种甲状腺激素（兆分之一）
  • 通过超滤-高效液相色谱（HPLC）-串联质谱（MS/MS）法同时分析牛血清样品中的 6 种游离甲状腺激素
  • 通过同位素稀释纳米超高效液相色谱–四极杆飞行时间质谱（LC-Q-TOF-MS）测定小鼠组织样品中的 6 种甲状腺激素
  • 使用液相色谱-串联质谱法（LC-MS/MS）测定大鼠血清样品中的三碘甲状腺原氨酸和甲状腺素

特點和優勢

  • 完全符合 ISO/IEC 17025 和 ISO 17034 认证
  • 附综合分析证书（CoA），包括稳定性、均匀性、浓度准确性、不确定性和可追溯性数据
  • 通过实时稳定性研究严格测试，以确保准确性和保质期
  • 使用合格的精密天平进行重量准备，以确保最小不确定性
  • 氩气环境下火焰密封，装入安瓿以便长期保存
  • 提供方便的 DEA 豁免格式，以提高实验室效率

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Flam. Liq. 2 - STOT SE 1

標靶器官

Eyes,Central nervous system

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

49.5 °F - closed cup

閃點（°C）

9.7 °C - closed cup

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分析證明 (COA)

Lot/Batch Number

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存取文件庫

Vasiliki Michopoulos et al.
Fertility and sterility, 99(7), 2084-2091 (2013-03-20)
To determine whether cognitive behavior therapy (CBT), which we had shown in a previous study to restore ovarian function in women with functional hypothalamic amenorrhea (FHA), could also ameliorate hypercortisolemia and improve other neuroendocrine and metabolic concomitants of in FHA.
Min Kyong Moon et al.
European journal of endocrinology, 168(6), 805-810 (2013-03-21)
Body adiposity, especially ectopic fat accumulation, has a range of metabolic and cardiovascular effects. This study aimed to investigate whether thyroid function is associated with various regional fat quantities in euthyroid subjects. A total of 100 euthyroid men (free triiodothyronine
V N Buriak et al.
Likars'ka sprava, (5)(5), 58-63 (2013-03-29)
The paper deals with etiopathogenetic and clinical peculiarities, and also therapeutic methods during the pathological processes in the thyroid system in the childhood. The most common of these processes is the diffuse nontoxic goiter, which results in abnormality of metabolic
Min Wang et al.
Neuro endocrinology letters, 34(1), 62-70 (2013-03-26)
To evaluate the poly(dextrogyr-levogyr) lactide acid-triiodothyronine (PDLLA-T3) seeded with Schwann cells conduit for repairing sciatic nerve defect. The rats were divided into three groups: autologous nerve transplantation (Group A), PDLLA-T3 + Schwann cells (Group B) and PDLLA + Schwann cells
Susana B Bravo et al.
The Journal of clinical endocrinology and metabolism, 98(6), 2431-2441 (2013-03-30)
Mechanisms of thyroid physiology and cancer are principally studied in follicular cell lines. However, human thyroid cancer lines were found to be heavily contaminated by other sources, and only one supposedly normal-thyroid cell line, immortalized with SV40 antigen, is available.
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文章

Simultaneous Determination of Free T3 and Free T4 in Serum

Determination of free thyroid hormones (T3 & T4) in serum by LC-MS/MS following a streamlined 1-hour BioSPME sample preparation.

條款

Online SPE/LC-MS Method for the Rapid Analysis of Thyroid Hormones in Plasma

Determination of the thyroid hormones T4, T3 and rT3 from plasma using an Ascentis Express RP-Amide cartridge to trap the analytes, and a Phenyl-Hexyl column to resolve them.

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. May I know its corresponding Antibody?

    1 answer

    1. This product is a Certified Reference Material intended for use as an identification, calibration, and quantification standard. Unfortunately, a corresponding antibody is not available.

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