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Merck
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T-075

Supelco

3,3′,5′-三碘代-甲腺原氨酸（rT3）标准液 溶液

100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

同義詞:

3,3',5'-三碘- L -甲状腺氨酸, rT(3), 逆转 T 3

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About This Item

經驗公式（希爾表示法）:
C15H12I3NO4
CAS號碼:
5817-39-0
分子量：:
650.97
MDL號碼:
MFCD00036864
分類程式碼代碼:
41116107
PubChem物質ID:
329826619
NACRES:
NA.24

等級

certified reference material

形狀

liquid

特點

Snap-N-Spike®/Snap-N-Shoot®

包裝

ampule of 1 mL

製造商／商標名

Cerilliant®

濃度

100 μg/mL in methanol with 0.1N NH3

技術

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

應用

clinical testing
clinical testing

格式

single component solution

儲存溫度

−20°C

SMILES 字串

N[C@@H](Cc1ccc(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1

InChI 密鑰

HZCBWYNLGPIQRK-LBPRGKRZSA-N

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相關類別

一般說明

反向T3，也称为rT3或3,3′,5′-三碘-L-甲状腺原氨酸，是甲状腺激素T3的一种生物失活形式，是在体内，特别是在压力期间产生的。在某些情况，如纤维肌痛、肝病和慢性疲劳综合症（CFS）时，更多的rT3会被产生，从而最大限度地减少所需要的甲状腺素（T4）向T3转化。通过LC-MS/MS测量反向T3血清浓度，以监测这些疾病和其他疾病对甲状腺激素水平的影响。

應用


  • Reverse T3 solution for thyroid research: Reverse T3 (3,3′,5′-Triiodo-L-thyronine) is utilized in biochemical assays to assess thyroid function and metabolism. Its role as an inactive metabolite of thyroid hormone makes it critical in studies investigating thyroid hormone balance and its impact on metabolic rate (Filetti et al., 1980).

  • High-purity rT3 thyroid hormone analog: Due to its high purity and stability, Reverse T3 is essential in thyroid metabolism research, providing a reliable standard for comparing thyroid activity and understanding its biological effects in health and disease states.

  • Thyroid metabolism research using Reverse T3: rT3 is instrumental in the study of thyroid hormone metabolism pathways, particularly in understanding the conversion processes of T4 to T3 and rT3, aiding in deciphering the complex regulatory mechanisms of thyroid hormones.

  • Reverse T3 in comparative endocrinology studies: The application of Reverse T3 solution extends to comparative endocrinology, where it is used to study the variations and similarities in thyroid hormone metabolism among different species, contributing to broader biological and evolutionary insights.

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

標靶器官

Eyes,Central nervous system

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

49.5 °F - closed cup

閃點（°C）

9.7 °C - closed cup

分析證明 (COA)

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存取文件庫

Gergő Tóth et al.
Journal of pharmaceutical and biomedical analysis, 76, 112-118 (2013-01-10)
A total of 30 species-specific partition coefficients of three thyroid hormones (thyroxine, liothyronine, reverse liothyronine) and their two biological precursors (monoiodotyrosine, diiodotyrosine) are presented. The molecules were studied using combined methods of microspeciation and lipophilicity. Microspeciation was carried out by
Pranati Sar et al.
PloS one, 6(6), e20861-e20861 (2011-06-21)
Thyroid hormones regulate cell proliferation, differentiation as well as apoptosis. However molecular mechanism underlying apoptosis as a result of thyroid hormone signaling is poorly understood. The antiapoptotic role of Senescence Marker Protein-30 (SMP30) has been characterized in response to varieties
Pamela D Noyes et al.
Aquatic toxicology (Amsterdam, Netherlands), 97(2), 142-150 (2010-01-19)
Polybrominated diphenyl ethers (PBDEs) are a class of flame retardant chemicals known to biomagnify in aquatic foodwebs. However, significant biotransformation of some congeners via reductive dehalogenation has been observed during in vivo and in vitro laboratory exposures, particularly in fish
Katarzyna Skórkowska-Telichowska et al.
Endokrynologia Polska, 63(4), 294-299 (2012-08-31)
Inhabitants living in areas with endemic dietary iodine intake deficiency develop nodular goitre. The aim of our study was to evaluate thyroid morphology and function among adults residing in Lower Silesia and to assess the effect on the thyroid gland
S Ruhla et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 43(2), 130-134 (2010-11-26)
Thyroid dysfunction has been shown to be associated with insulin resistance (IR). This may involve peripheral thyroid hormone metabolism, which is assumed to be reflected by the ratio triiodothyronine/reverse triiodothyronine (T3/rT3-ratio). To explore a potential association between the T3/rT3-ratio and
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Online SPE/LC-MS Method for the Rapid Analysis of Thyroid Hormones in Plasma

Determination of the thyroid hormones T4, T3 and rT3 from plasma using an Ascentis Express RP-Amide cartridge to trap the analytes, and a Phenyl-Hexyl column to resolve them.

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