推薦產品
形狀
powder
包裝
pkg of 1 × 5 mg (860660P-5mg)
製造商／商標名
Avanti Research™ - A Croda Brand 860660P
脂質類型
sphingolipids
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
OC[C@@](N)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCCCC
InChI
1S/C20H41NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(21)18-22/h16-17,19-20,22-23H,2-15,18,21H2,1H3/b17-16+/t19-,20+/m0/s1
InChI 密鑰
HTJSZHKGNMXZJN-YIVRLKKSSA-N
一般說明
Sphingosine (d20:1), also known as icosasphingosine, is a synthetic sphingosine with 20 carbon long chain bases (LCB).[1] It is directly produced by the sphingolipid de novo synthesis pathway and not by hydrolysis of complex sphingolipids.[2] In higher animals, it is one of the most abundant sphingoid bases of gangliosides.[3]
應用
Sphingosine (d20:1) has been used as a reference substance in liquid chromatography/tandem mass spectrometry analysis to quantitatively analyze sphingolipids with C20- long chain bases in human central nervous tissue.[2]
生化／生理作用
Sphingosine (d20:1) or C20-sphingosine acts as an intermediate in the synthesis of ceramides, which are vital components of mammalian epidermis. It may be involved in regulation of epidermal differentiation.[4] C20 long chain bases-containing sphingolipids might exhibit detrimental effect on protein homeostasis and neural functions.[5]
包裝
5 mL Amber Glass Screw Cap Vial (860660P-5mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Lihong Zhao et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(42), 12962-12967 (2015-10-07)
Sphingolipids typically have an 18-carbon (C18) sphingoid long chain base (LCB) backbone. Although sphingolipids with LCBs of other chain lengths have been identified, the functional significance of these low-abundance sphingolipids is unknown. The LCB chain length is determined by serine
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
Alfred H Merrill
The Journal of biological chemistry, 277(29), 25843-25846 (2002-05-16)
P W Wertz et al.
Biochimica et biophysica acta, 1002(2), 213-217 (1989-04-03)
Sphingosines and phytosphingosines serve as intermediates in the synthesis of ceramides and glucosylceramides, which are prominent components of mammalian epidermis. In the present study, we have investigated the possibility that free sphingoid bases also may be present in epidermal tissue.
Thomas Kolter
ISRN biochemistry, 2012, 506160-506160 (2012-01-01)
Gangliosides are sialic acid-containing glycosphingolipids. They occur especially on the cellular surfaces of neuronal cells, where they form a complex pattern, but are also found in many other cell types. The paper provides a general overview on their structures, occurrence
Rajkumar Vutukuri et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(3), 3932-3942 (2020-01-17)
Sphingosine 1-phosphate (S1P) signaling influences numerous cell biological mechanisms such as differentiation, proliferation, survival, migration, and angiogenesis. Intriguingly, our current knowledge is based solely on the role of S1P with an 18-carbon long-chain base length, S1P d18:1. Depending on the
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務
