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重要文件

860641P

Avanti

D-苏式-鞘胺醇-1-磷酸(d17:1)

Avanti Research - A Croda Brand

同義詞:

D-赤型-鞘氨醇-1-磷酸(C17碱)

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About This Item

經驗公式(希爾表示法):
C17H36NO5P
CAS號碼:
分子量::
365.45
分類程式碼代碼:
12352211
NACRES:
NA.25
暫時無法取得訂價和供貨情況

形狀

powder

包裝

pkg of 1 × 1 mg (860641P-1mg)
pkg of 1 × 5 mg (860641P-5mg)

製造商/商標名

Avanti Research - A Croda Brand

脂質類型

sphingolipids

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

CCCCCCCCCCCC/C=C/[C@@]([H])(O)[C@]([NH3+])([H])COP([O-])(O)=O

InChI

1S/C17H36NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(19)16(18)15-23-24(20,21)22/h13-14,16-17,19H,2-12,15,18H2,1H3,(H2,20,21,22)/b14-13+/t16-,17+/m0/s1

InChI 密鑰

VITGNIYTXHNNNE-LHMZYYNSSA-N

一般說明

鞘氨醇-1-磷酸(S1P)(d17:1)是神经酰胺的一种衍生物。[1]它是鞘氨醇C17类似物的磷酸化形式。[2]S1P是一种两性鞘脂。它存在于昆虫、酵母和植物中。

應用

鞘氨醇-1-磷酸(d17:1)已被用作内标,通过质谱对生物学材料和组织样品中的鞘氨醇-1-磷酸(S1P)进行定量。[3][4][5]

生化/生理作用

鞘氨醇-1-磷酸(S1P)可有助于细胞的生长和功能。[1]它还有助于多种生理和细胞过程,如动脉粥样硬化、炎症、免疫、肿瘤发生和细胞增殖。[2]S1P在动物细胞中可起到信号脂质的作用。

包裝

5 mL 棕色玻璃螺旋盖小瓶 (860641P-1mg)
5 mL 棕色玻璃螺旋盖小瓶 (860641P-5mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


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Cecilia Frej et al.
Analytical and bioanalytical chemistry, 407(28), 8533-8542 (2015-09-18)
Sphingosine 1-phosphate (S1P) is a signalling sphingolipid affecting multiple cellular functions of vascular and immune systems. It circulates at submicromolar levels bound to HDL-associated apolipoprotein M (apoM) or to albumin. S1P in blood is mainly produced by platelets and erythrocytes
Constantin Bode et al.
Methods in molecular biology (Clifton, N.J.), 874, 33-44 (2012-04-25)
Liquid chromatography coupled to tandem mass spectrometry has evolved as the method of choice for the detection of sphingolipid metabolites due to its high sensitivity and superior specificity compared to other methodological approaches. Here, we describe a simple and robust
Mina Mirzaian et al.
Clinica chimica acta; international journal of clinical chemistry, 459, 36-44 (2016-05-26)
We developed a mass spectrometric procedure to quantify sphingosine-1-phosphate (S1P) in biological materials. The use of newly synthesized (13)C5 C18-S1P and commercial C17-S1P as internal standards rendered very similar results with respect to linearity, limit of detection and limit of
Eri Sakai et al.
The journal of applied laboratory medicine, 5(4), 656-670 (2020-05-15)
Sphingolipids have been demonstrated to be involved in many human diseases. However, measurement of sphingolipids, especially of sphingosine 1-phosphate (S1P) and dihydro-sphingosine 1-phosphate (dhS1P), in blood samples requires strict sampling, since blood cells easily secrete these substances during sampling and
Pernille M Christensen et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30(6), 2351-2359 (2016-03-10)
Apolipoprotein M (ApoM) transports sphingosine-1-phosphate (S1P) in plasma, and ApoM-deficient mice (Apom(-/-)) have ∼50% reduced plasma S1P levels. There are 5 known S1P receptors, and S1P induces adherens junction formation between endothelial cells through the S1P1 receptor, which in turn

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