810215P

C12-NBD Phytosphingosine

N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-phytosphingosine, powder

• 同義詞: N-(NBD-Aminolauroyl)phytosphingosine
• 經驗公式（希爾表示法）: C₃₆H₆₃N₅O₇
• CAS號碼: 388566-94-7
• 分子量：: 677.91
• MDL號碼: MFCD02259274
• 分類程式碼代碼: 12352211
• NACRES: NA.25

屬性

• 化驗: >99% (TLC)
• 形狀: powder
• 包裝: pkg of 1 × 50 μg (810215P-50ug)
• 製造商／商標名: Avanti Research^™ - A Croda Brand 810215P
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• SMILES 字串: N[C@H]([C@H](O)[C@H](O)CCCCCCCCCCCCCC)CO
• InChI: 1S/C18H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20/h16-18,20-22H,2-15,19H2,1H3/t16-,17+,18-/m0/s1
• InChI 密鑰: AERBNCYCJBRYDG-KSZLIROESA-N

描述

一般說明

C12-NBD Phytosphingosine is a fluorescent derivative of the naturally occurring lipid compound, phytosphingosine which is localised in skin, kidney and intestines.[1][2]

Phytosphingosine is a ceramide molecule localized to the stratum corneum.[3]

應用

C12-NBD Phytosphingosine has been used as a substrate in ceramidase activity assay to study enzyme activity.[4]

C12-NBD phytosphingosine has been used as a substrate to assay ceramidase activity.[4]

生化／生理作用

In vitro studies using human epidermis model shows that melanin production is prevented by phytosphingosine. Hence, it is widely used in cosmetics.[5]

Phytosphingosine (PHS) is a sphingoid lipid molecule which is known to exhibit antimicrobial and anti-inflammatory action. PHS can has the ability to increase the production of keratinocyte differentiation marker proteins, such as transglutaminase 1 and involucrin, that are responsible for the development of cornifed envelope.[2] PHS metabolism results in the formation of glycerophospholipids, sphingolipids and even-numbered fatty acids which mainly include palmitic acid.[6]

包裝

5 mL Amber Glass Screw Cap Vial (810215P-50ug)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全資訊

• 儲存類別代碼: 11 - Combustible Solids