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重要文件

810174P

Avanti

16:0-12:0 NBD PA

Avanti Research™ - A Croda Brand 810174P, powder

同義詞:

1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphate (ammonium salt)

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About This Item

經驗公式（希爾表示法）:
C37H66N5O11P
CAS號碼:
474942-96-6
分子量：:
787.92
MDL號碼:
MFCD00467278
分類程式碼代碼:
12352211
NACRES:
NA.25
暫時無法取得訂價和供貨情況

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 1 mg (810174P-1mg)

製造商／商標名

Avanti Research™ - A Croda Brand 810174P

運輸包裝

dry ice

儲存溫度

−20°C

一般說明

Phosphatidic acid (PA) is a simple anionic cellular glycerophospholipid possessing a phosphomonoester polar head group and two long hydrophobic acyl chains.[1] 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) PA is a fluorophore labeled phospholipid having 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) at the sn-2 fatty acid of PA.[2]

應用

16:0-12:0 NBD PA or 1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphate (ammonium salt) is suitable:
  • to incubate cells for the imaging of lyso phosphatidylcholine (PC) in P. falciparum live cells[3]
  • as a component of separation buffer for the separation of phosphoinositides and sphingolipids in the microchip devices[4]
  • in cytidine diphosphate diacylglycerol (CDP-DAG) synthase activity assay[5]

生化／生理作用

Phosphatidic acid (PA) influences membrane fusion and membrane fission events[1] and membrane curvature.[6] It acts as a signaling molecule for various cellular processes including membrane trafficking and sperm hyper-activation.[7]

包裝

5 mL Amber Glass Screw Cap Vial (810174P-1mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

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分析證明 (COA)

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Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria
Tamura Y, et al.
Cell Metabolism, 17(5), 709-718 (2013)
Yasushi Tamura et al.
Cell metabolism, 17(5), 709-718 (2013-04-30)
CDP-diacylglycerol (CDP-DAG) is central to the phospholipid biosynthesis pathways in cells. A prevailing view is that only one CDP-DAG synthase named Cds1 is present in both the endoplasmic reticulum (ER) and mitochondrial inner membrane (IM) and mediates generation of CDP-DAG
Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties
Putta P, et al.
Biochimica et Biophysica Acta, 1858(11), 2709-2716 (2016)
A Chauhan et al.
Neurochemical research, 25(3), 423-429 (2000-04-13)
Fibrillar amyloid beta-protein (Abeta) is the major protein of amyloid plaques in the brains of patients with Alzheimer's disease (AD). The mechanism by which normally produced soluble Abeta gets fibrillized in AD is not clear. We studied the effect of
Priya Putta et al.
Biochimica et biophysica acta, 1858(11), 2709-2716 (2016-08-03)
Phosphatidic acid (PA) is a crucial membrane phospholipid involved in de novo lipid synthesis and numerous intracellular signaling cascades. The signaling function of PA is mediated by peripheral membrane proteins that specifically recognize PA. While numerous PA-binding proteins are known
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