推薦產品
化驗
>99% (TLC)
形狀
liquid
包裝
pkg of 1 × 5 mL (800100C-10mg)
pkg of 1 × 5 mL (800100C-25mg)
製造商／商標名
Avanti Research™ - A Croda Brand 800100C
濃度
2 mg/mL (800100C-10mg)
5 mg/mL (800100C-25mg)
脂質類型
neutral lipids
neutral glycerides
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
O([C@H](COC(=O)CCCCCCC\C=C/CCCCCCCC)CO)C(=O)C
InChI
1S/C23H42O5/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)27-20-22(19-24)28-21(2)25/h10-11,22,24H,3-9,12-20H2,1-2H3/b11-10-/t22-/m0/s1
InChI 密鑰
PWTCCMJTPHCGMS-YRBAHSOBSA-N
一般說明
18:1-2:0 DG, also called 1-oleoyl-2-acetyl-sn-glycerol (OADG), is a synthetic analog of diacyl glycerol (DAG) and is membrane permeable.[1]
應用
18:1-2:0 DG (1-oleoyl-2-acetyl-sn-glycerol) has been used as a diacyl glycerol (DAG) analog to test its impact on DAG-sensitive channels in thalamocortical (TC) neurons.[2] It may be used as an internal standard for retention time calibration in ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF MS) for blood sample lipid quantification.[3] It may also be used as a protein kinase C (PKC) activator in adrenal glands.[4]
生化／生理作用
1-oleoyl-2-acetyl-sn-glycerol (OAG) has ability to activate protein kinase C (PKC) .[4] It also inhibits TWIK-related acid-sensitive (TASK)-like potassium channels in peripheral arterial chemoreceptors.[2] OAG stimulates 5-lipooxygenase (5-LO) in human polymorphonuclear leukocytes (PMNL).[5] It also inhibits mitochondrial permeability transition pore (MPTP) formation and prevents fatty acid release and necrosis in lung fibroblasts.[6]
包裝
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800100C-10mg)
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800100C-25mg)
儲存和穩定性
Diacylglycerols are conveniently stored in chloroform solutions in glass vials with PTFE-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.
其他說明
Delivery to cells: Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.
Effective concentration: Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.
Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
訊號詞
Danger
危險分類
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
標靶器官
Central nervous system, Liver,Kidney
水污染物質分類（WGK）
WGK 3
sn-1,2-dioctanoylglycerol: a Cell Permeable Diacylglycerol That Mimics Phorbol Diester Action on the Epidermal Growth Factor Receptor and Mitogenesis
Davis, R.J, et.al.
The Journal of Biological Chemistry, 260, 1562-1566 (1985)
Diacylglycerols and Phorbol Diesters Induce Leukemic Cell Differentiation via a Common Mechanism.
Ebeling, J.G, et.al.
Proceedings of the National Academy of Sciences of the USA, 82, 815-819 (1985)
Specificity and Mechanism of Protein Kinase C Activation by sn-1,2-diacylglycerols.
Ganong, B.R, et. al.
Proceedings of the National Academy of Sciences of the USA, 83, 1184-1188 (1986)
Exogenous sn-1,2-diacylglycerols Containing Saturated Fatty Acids Functions as Bioregulators of Protein Kinase C in Human Platelets.
Lapetina, E.G, et. al.
The Journal of Biological Chemistry, 260, 1358-1361 (1985)
Pawan Bista et al.
The Journal of physiology, 593(1), 127-144 (2015-01-06)
During the behavioural states of sleep and wakefulness thalamocortical relay neurons fire action potentials in high frequency bursts or tonic sequences, respectively. The modulation of specific K(+) channel types, termed TASK and TREK, allows these neurons to switch between the
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