791056P

2-OHOA

2-hydroxyoleic acid (sodium salt), powder

• 同義詞: Minerval; NaCHOleate; 2OHOA
• 經驗公式（希爾表示法）: C₁₈H₃₃NaO₃
• CAS號碼: 1229114-68-4
• 分子量：: 320.44
• 分類程式碼代碼: 12352211
• NACRES: NA.25

屬性

• 化驗: >99% (TLC)
• 形狀: powder
• 包裝: pkg of 1 × 1 g (791056P-1g)
• 製造商／商標名: Avanti Research^™ - A Croda Brand 791056P
• 脂質類型: neutral lipids; neutral glycerides
• 運輸包裝: dry ice
• 儲存溫度: −20°C

描述

一般說明

2-hydroxyoleic acid (2-OHOA) is a synthetic and non-β oxidation-metabolizable oleic acid derivative. It contains 18 carbon atoms in its fatty acid chain length.

應用

2-hydroxyoleic acid (2-OHOA) is suitable for use:

• to study its antihypertensive action in adult spontaneously hypertensive rats (SHRs)
• to study the chemical structure-effect relation of 2-OHOA in the reduction of body weight in rats
• as an antitumor compound, to study its effect on xenografts lipidome based on imaging mass spectrometry (IMS)

生化／生理作用

2-Hydroxy Oleic Acid is an inducer of cell cycle arrest and apoptosis in several cancer cell lines, including glioma, leukemia, breast and colon cancer lines. 2-Hydroxy Oleic Acid increases sphingomyelin (SM) levels in the membranes of tumor cells, which typically display decreased SM membrane content, and remodeled membranes, compared with normal cells. The compound has no effect on SM levels in non-cancer cells.

2-hydroxyoleic acid (2-OHOA) acts as a potential antihypertensive agent. Oral administration of 2-OHOA is used to reduce body weight.

包裝

20 mL Clear Glass Screw Cap Vial (791056P-1g)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全資訊

• 儲存類別代碼: 11 - Combustible Solids