131303P

Cerebrosides (Brain)

Avanti Research^™ - A Croda Brand

• 同義詞: Total Cerebrosides (Brain, Porcine)
• CAS號碼: 383906-25-0
• MDL號碼: MFCD18427707
• 分類程式碼代碼: 12352211
• NACRES: NA.25

屬性

• 化驗: >99% (TLC)
• 形狀: powder
• 包裝: pkg of 1 × 25 mg (131303P-25mg)
• 製造商／商標名: Avanti Research^™ - A Croda Brand
• 脂質類型: sphingolipids
• 運輸包裝: dry ice
• 儲存溫度: −20°C

描述

一般說明

Cerebrosides are glycosphingolipids with either glucose or galactose as a polar head group. They comprise the major component of the myelin lipids. Cerebrosides are part of non-neural cells including the epithelial cells associated with skin and the digestive system.[1] Cerebrosides are amphipathic in nature.[2]

The total brain cerebrosides appear as a double spot on thin layer chromatography (chloroform/methanol/water, 65:25:4 v/v). The top spot corresponds to ceresine which contain non-hydroxylated fatty acids, and the bottom spot corresponds to phrenosin which contain hydroxylated fatty acids.This Natural Lipid is a mixture and the structure shown above is only representative of one possible structure present in the product. Refer to chart for average fatty acid distribution.

應用

Cerebrosides (Brain) has been used:

• in the coating of coverslips for neurite outgrowth assay of retinal ganglion cells[3]
• in reconstruction of the apical membrane of Madin-Darby canine kidney (MDCK) cells[4]
• in the preparation of liposomes to mimic the MDCK cell membrane for permeability studies[5]

生化／生理作用

Cerebrosides regulate a variety of physiological processes like cell growth, survival and multiplication. They coordinate membrane trafficking and inhibit apoptosis. Inborn metabolic disorder, Gaucher′s disease is associated with elevated levels of cerebrosides.[6]. Additionally, cerebrosides provide structural support to the membranes and mediate intracellular communication.[2] Accumulation of galactocerebrosides is associated with tumors. It also serves as a receptor for human immune deficiency virus (HIV) glycoprotein.[6] The porcine cerebroside and ganglioside (CPCG) is used in treating neurotoxicity induced by the drug oxaliplatin in digestive system tumors.[7]

包裝

5 mL Amber Glass Screw Cap Vial (131303P-25mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全資訊

• 儲存類別代碼: 11 - Combustible Solids