923907

6F,C5-Pomalidomide-piperazine-piperidine-4-carbothioamide hydrochloride

• 同義詞: 2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-(4-(piperidine-4-carbonothioyl)piperazin-1-yl)isoindoline-1,3-dione hydrochloride, Crosslinker–E3 ligase ligand conjugate, Protein degrader building block
• 經驗公式（希爾表示法）: C₂₃H₂₆FN₅O₄S · xHCl
• 分子量：: 487.55 (free base basis)
• 分類程式碼代碼: 12352101
• NACRES: NA.21

屬性

• ligand: 6F,C5-Pomalidomide
• 品質等級: 100
• 反應適用性: reactivity: carboxyl reactive; reagent type: ligand-linker conjugate
• 官能基: amine
• 儲存溫度: 2-8°C
• SMILES 字串: O=C1C(N2C(C(C=C(F)C(N3CCN(C(C4CCNCC4)=S)CC3)=C5)=C5C2=O)=O)CCC(N1)=O.Cl
• InChI: 1S/C23H26FN5O4S.ClH/c24-16-11-14-15(22(33)29(21(14)32)17-1-2-19(30)26-20(17)31)12-18(16)27-7-9-28(10-8-27)23(34)13-3-5-25-6-4-13;/h11-13,17,25H,1-10H2,(H,26,30,31);1H
• InChI 密鑰: KFKOGFHONWLHKV-UHFFFAOYSA-N

描述

應用

Protein degrader building block 6F,C5-Pomalidomide-piperazine-piperidine-4-carbothioamide hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC^® (proteolysis-targeting chimeras) research. This conjugate contains a Cereblon (CRBN) recruiting ligand, a rigid linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

其他說明

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全資訊

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H360D
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Repr. 1B
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable