906298

3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine

• 同義詞: Probe building block for photoaffinity labeling, Suzuki-Miyaura-compatible multifunctional photo probe building block, Trifluoromethyl diazirine aryl bromide
• 經驗公式（希爾表示法）: C₈H₄BrF₃N₂
• CAS號碼: 952143-02-1
• 分子量：: 265.03
• MDL號碼: MFCD31667367
• 分類程式碼代碼: 12352101
• NACRES: NA.22

屬性

• 化驗: ≥95%
• 形狀: liquid
• 反應適用性: reagent type: cross-linking reagent
• 儲存溫度: 2-8°C
• SMILES 字串: BrC1=CC=C(C2(N=N2)C(F)(F)F)C=C1
• InChI: 1S/C8H4BrF3N2/c9-6-3-1-5(2-4-6)7(13-14-7)8(10,11)12/h1-4H
• InChI 密鑰: YBEXZCGWGWNLQQ-UHFFFAOYSA-N

描述

應用

3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine is a Suzuki-Miyaura (S−M)-compatible building block tailored for the design of photoaffinity probes (PAPs). Photoaffinity labeling (PAL) is of growing interest in chemical biology and drug discovery research for use in protein profiling; covalent inhibitors; protein-protein interactions and complexes; and target engagement, identification, or validation studies. Diazirines are desirable photoactivable groups for chemical probes; however, their installation is not always straightforward. In response, diazirine-tolerant S-M coupling conditions were developed by Ichiishi, et al, using 3-(4-bromophenyl)-3-(trifluoromethyl)-3H-diazirine and shown to be efficient and scalable with minimal perturbation of the diazirine.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

其他說明

Reducing Limitation in Probe Design: The Development of a Diazirine-Compatible Suzuki-Miyaura Cross Coupling Reaction

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable