全部照片(3)

文件

901493

(S,R,S)-AHPC-PEG₁-NH₂ hydrochloride

Name: (S,R,S)-AHPC-PEG1-NH2 hydrochloride
Brand: ALDRICH

≥95%

同義詞:

(2S,4R)-1-((S)-2-(2-(2-Aminoethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC^® research, Template for synthesis of targeted protein degrader, VH032 conjugate

登入查看組織和合約定價

全部照片(3)

About This Item

經驗公式（希爾表示法）:

C₂₆H₃₇N₅O₅S · xHCl

分子量：:

531.67 (free base basis)

分類程式碼代碼:

12352101

NACRES:

NA.22

推薦產品

Slide 1 of 10

1 of 10

Sigma-Aldrich

901488

(S,R,S)-AHPC-PEG₂-NH₂ hydrochloride

Sigma-Aldrich

901848

(S,R,S)-AHPC-PEG₄-NH₂ hydrochloride

Sigma-Aldrich

901490

(S,R,S)-AHPC hydrochloride

Sigma-Aldrich

917818

(S,R,S)-AHPC-C₉-NH₂ hydrochloride

Sigma-Aldrich

901511

(S,R,S)-AHPC-PEG₃-NH₂ hydrochloride

Sigma-Aldrich

901487

(S,S,S)-AHPC hydrochloride

Sigma-Aldrich

901860

(S,R,S)-AHPC-PEG₆-NH₂ hydrochloride

Sigma-Aldrich

920762

(S,R,S)-AHPC-benzyl-piperazine hydrochloride

Sigma-Aldrich

904651

(S,R,S)-AHPC-PEG₃-azide

Sigma-Aldrich

901534

(S,R,S)-AHPC-C₆-CO₂H hydrochloride

ligand

VH032

品質等級

100

化驗

≥95%

形狀

powder or crystals

反應適用性

reactivity: carboxyl reactive
reagent type: ligand-linker conjugate

官能基

amine

儲存溫度

2-8°C

SMILES 字串

O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCN)=O)=O.Cl

應用

Protein degrader builiding block (S,R,S)-AHPC-PEG₁-NH₂ (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Automate your VHL-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)

其他說明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

輸入產品批次/批號來搜索分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

已經擁有該產品？

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

客戶也查看了

Slide 1 of 9

1 of 9

Sigma-Aldrich

906123

(S,R,S)-AHPC-PEG₂-butyl amine hydrochloride

Sigma-Aldrich

901513

Pomalidomide-PEG₂-NH₂ hydrochloride

Sigma-Aldrich

901831

Pomalidomide-PEG₅-NH₂hydrochloride

Sigma-Aldrich

905232

(S,R,S)-AHPC-C₆-PEG₃-butyl amine hydrochloride

Sigma-Aldrich

905275

(S,R,S)-AHPC-PEG₆-butyl amine hydrochloride

Sigma-Aldrich

901487

(S,S,S)-AHPC hydrochloride

Sigma-Aldrich

901503

(S,R,S)-AHPC-PEG₁-Alkyne

Sigma-Aldrich

901496

Pomalidomide-C₆-CO₂H

Sigma-Aldrich

901500

Pomalidomide-C₃-CO₂H

Small-Molecule PROTACS: New Approaches to Protein Degradation.

Momar Toure et al.

Angewandte Chemie (International ed. in English), 55(6), 1966-1973 (2016-01-13)

The current inhibitor-based approach to therapeutics has inherent limitations owing to its occupancy-based model: 1) there is a need to maintain high systemic exposure to ensure sufficient in vivo inhibition, 2) high in vivo concentrations bring potential for off-target side effects, and 3) there is

Impact of linker length on the activity of PROTACs.

Kedra Cyrus et al.

Molecular bioSystems, 7(2), 359-364 (2010-10-06)

Conventional genetic approaches have provided a powerful tool in the study of proteins. However, these techniques often preclude selective manipulation of temporal and spatial protein functions, which is crucial for the investigation of dynamic cellular processes. To overcome these limitations

Targeted Protein Degradation: from Chemical Biology to Drug Discovery.

Philipp M Cromm et al.

Cell chemical biology, 24(9), 1181-1190 (2017-06-27)

Traditional pharmaceutical drug discovery is almost exclusively focused on directly controlling protein activity to cure diseases. Modulators of protein activity, especially inhibitors, are developed and applied at high concentration to achieve maximal effects. Thereby, reduced bioavailability and off-target effects can

Small-Molecule PROTACS: New Approaches to Protein Degradation.

Momar Toure et al.

Angewandte Chemie (International ed. in English), 55(6), 1966-1973 (2016-01-13)

The current inhibitor-based approach to therapeutics has inherent limitations owing to its occupancy-based model: 1) there is a need to maintain high systemic exposure to ensure sufficient in vivo inhibition, 2) high in vivo concentrations bring potential for off-target side effects, and 3) there is

文章

針對蛋白質降解的降解器構件

Protein Degrader Building Blocks 是一系列交聯劑-E3 配體結合物，具有懸垂功能基團，可與目標配體共價連結。

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務

文件

(S,R,S)-AHPC-PEG1-NH2 hydrochloride

≥95%

About This Item

推薦產品

屬性

ligand

品質等級

化驗

形狀

反應適用性

官能基

儲存溫度

SMILES 字串

相關類別

描述

應用

其他說明

法律資訊

相關產品

相關產品

安全資訊

儲存類別代碼

水污染物質分類（WGK）

閃點（°F）

閃點（°C）

文件

分析證明 (COA)

已經擁有該產品？

客戶也查看了

同儕審查論文

條款與法條

文章

(S,R,S)-AHPC-PEG₁-NH₂ hydrochloride