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重要文件

765511

Sigma-Aldrich

官能化金纳米粒子COOH

20 nm diameter, carboxylic acid functionalized, PEG 5000 coated, OD 50, dispersion in H2O

同義詞:

Au NP COOH, 金胶体

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About This Item

分類程式碼代碼:
12162002
NACRES:
NA.23
暫時無法取得訂價和供貨情況

材料

PEG 5000

品質等級

形狀

dispersion in H2O
nanoparticles

包裝

poly bottle of 1 mL

外徑

50

直徑

20 nm

pH值

6.0-8.0 (25 °C)

溶解度

water: miscible

密度

1.00 g/cm3

λmax

520 nm

官能基

carboxylic acid

儲存溫度

2-8°C

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一般說明

Carboxylic acid functionalized GNPs form conjugates with various protein molecules due to the electrostatic attraction between negatively charged carboxylate groups and positively charged amino groups of protein.[1]

應用

功能化颗粒已被广泛用于研究纳米颗粒[2]的细胞摄取和靶向药物递送[3]
Carboxylic acid functionalized, PEG 5000 coated, OD 50, and H2O dispersed gold nanoparticles can be potentially used in the development of biosensors, cancer-cell imaging, drug delivery, and photothermal therapy.[4]
AuNPs may be used to prepare SARS-CoV-2 conjugate for COVID-19 detection using lateral flow immunoassay technique.[5][6] It may also be used in the immobilization of antibodies to improve the sensitivity of optical fiber sensors for the screening of COVID-19.[7] It can also be deposited on the titanium electrode for the formation of a miniaturized device for the electrochemical detection of DNA hybridization.[7]
The carboxylic acid group binds with various proteins and can be used in targeted drug delivery and gene therapy. [8]

特點和優勢

Decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. The PEG increases the stability of the nanoparticles and prevents agglomeration.[8]

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis
Li Z, et al.
Journal of Medical Virology, 6, 2071-2071 (2020)
Size-dependent in vivo toxicity of PEG-coated gold nanoparticles
Zhang X, et al.
International journal of nanomedicine, 6, 2071-2071 (2011)
Nishima Wangoo et al.
Journal of colloid and interface science, 323(2), 247-254 (2008-05-20)
We report a novel strategy for the synthesis of aqueous stable, carboxylated gold nanoparticles (GNPs) by using glutamic acid as the reducing agent. The ratio of chloroaurate ions, AuCl(-)(4) to glutamic acid was optimized in the reaction medium to obtain
Optical Fiber Sensors for Rapid Screening of COVID-19
Nag P, et al.
Transactions of the Indian National Academy of Engineering, 143(9), 1-4 (2020)
Recent advances in nanoparticle-based lateral flow immunoassay as a point-of-care diagnostic tool for infectious agents and diseases
Banerjee R and Jaiswal A
Analyst, 143(9), 1970-1996 (2018)

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