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Sigma-Aldrich

DL-α-生育酚甲氧基聚乙二醇琥珀酸酯

greener alternative

同義詞:

TPGS-750-M

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About This Item

CAS號碼:
MDL號碼:
分類程式碼代碼:
51171641
NACRES:
NA.22
暫時無法取得訂價和供貨情況

形狀

powder

品質等級

反應適用性

reagent type: catalyst
reaction type: C-H Activation

reagent type: surfactant

環保替代產品特色

Catalysis
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

轉變溫度

Tm 29-34

環保替代類別

一般說明

我们致力于为您带来更加绿色的替代产品,这些产品遵守一项或多项绿色化学12项原则。本品(TPGS-750-M) 是许多过渡金属催化交叉偶联反应采用的主要表面活性剂,已强化催化效率。点击此处,查看更多详情。
要了解更多信息,请访问Bruce Lipshutz教授的教授和产品门户网站

應用

DL-α-生育酚甲氧基聚乙二醇琥珀酸酯(TPGS-750-M)是天然维生素E的可生物降解和水溶性衍生物,在水中金属催化的交叉偶联反应中用作环境良性非离子表面活性剂。它用于Heck、Suzuki-Miyaura、Sonogashira和Negishi之类的偶联反应。[1]它也可用于胺化、C-H活化和烯烃复分解反应。[1][2]
TPGS-750-M也可用于:
  • 芳基和杂芳基卤化物与氮、氧、硫亲核试剂在温和条件下的亲核芳香取代反应。[3]
  • 喹喔啉酮经C(sp2)羟化反应制取喹喔啉-2,3二酮。[4]
  • 使用铜催化剂的胺的分子内N-芳基化。[2]

其他說明

观看 Lipshutz 教授在本次网络研讨会上谈论 TPGS-750-M:
从毫克到公斤:遵循自然引导的合成化学′

相關產品

產品號碼
描述
訂價

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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存取文件庫

Application of nanoparticle mediated N-arylation of amines for the synthesis of pharmaceutical entities using vit-E analogues as amphiphiles in water
Kumar A and Bishnoi AK
Royal Society of Chemistry Advances, 5(26), 20516-20520 (2015)
Metal-Free C3 Hydroxylation of Quinoxalin-2 (1H)-ones in Water
Peng S, et al.
Advanced Synthesis & Catalysis, 361(24), 5721-5726 (2019)
TPGS-750-M: a second-generation amphiphile for metal-catalyzed cross-couplings in water at room temperature
Lipshutz BH, et al.
The Journal of Organic Chemistry, 76(11), 4379-4391 (2011)
Metal-Free C3 Hydroxylation of Quinoxalin-2 (1H)-ones in Water
Peng S, et al.
advanced synthesis and catalysis, 361(24), 5721-5726 (2019)
Nucleophilic aromatic substitution reactions in water enabled by micellar catalysis
Isley NA, et al.
Organic Letters, 17(19), 4734-4737 (2015)

文章

Lipshutz及其同事最近开发了第二代技术,用于基于聚氧乙戊基-α-生育酚琥珀酸酯衍生物TPGS-750-M的原始PTS表面活性剂。

Micellular catalysis has provided the ability to carry out several commonly used transformations used in the synthetic community to be carried out in water.

Lipshutz and co-workers have recently developed a second generation technology to their original PTS-enabling surfactant based on the polyoxyethanyl-α-tocopheryl succinate derivative, TPGS-750-M.

Surfactants for efficient reactions in water as a green chemistry alternative.

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條款

TPGS-750-M surfactant enables various reactions in water at room temperature, enhancing efficiency and versatility in synthesis.

TPGS-750-M 表面活化劑可在室溫下於水中進行各種反應,提高合成的效率與多樣性。

相關內容

Micellular catalysis has provided the ability to carry out several commonly used transformations used in the synthetic community to be carried out in water.

TPGS-750-M, a second generation surfactant, may be used for Suzuki-Miyaura Reactions in Water at Room Temperature

TPGS-750-M, a second generation surfactant, may be used in the Buchwald-Hartwig Amination Reaction in Water at Room Temperature.

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