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重要文件

700312

Sigma-Aldrich

氧化铁(II,III),磁性纳米颗粒 溶液

10 nm avg. part. size, 5 mg/mL in toluene

同義詞:

磁性氧化铁纳米颗粒, 磁铁矿, 超顺磁氧化铁纳米颗粒

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About This Item

經驗公式(希爾表示法):
Fe3O4
CAS號碼:
分子量::
231.53
MDL號碼:
分類程式碼代碼:
12352302
PubChem物質ID:
NACRES:
NA.23
暫時無法取得訂價和供貨情況

形狀

nanoparticles
solution

品質等級

濃度

5 mg/mL in toluene

磁化

>45 emu/g (at ambient temperature under 4500 Oe)

樣品平均尺寸

10 nm

粒徑

9-11 nm (TEM; conforms)

密度

0.865 g/mL at 25 °C

SMILES 字串

O=[Fe].O=[Fe]O[Fe]=O

InChI

1S/3Fe.4O

InChI 密鑰

SZVJSHCCFOBDDC-UHFFFAOYSA-N

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一般說明

氧化铁(II、III)磁性纳米颗粒溶液(Fe3O4)是一种有机溶剂分散纳米颗粒溶液,可通过乙酰丙酮铁在2-吡咯烷酮热分解合成。基于其磁性能、颗粒大小和表面性质,它主要应用于生物医学领域。[1][2]
含有<1.0% 油酸稳定配体。
浓度5mg/ml包括纳米晶体加配体的总重量。

應用

Fe3O4可用作肿瘤细胞的靶向和成像,应用于癌症治疗。它还可用于从新鲜全血中分离肿瘤细胞。[3][4]此外,它还可用作药物传递系统和磁共振成像(MRI)的有效材料。[5][6]

訊號詞

Danger

危險分類

Aquatic Chronic 3 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 - STOT SE 3

標靶器官

Central nervous system

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

45.0 °F

閃點(°C)

7.2 °C

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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分析證明 (COA)

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存取文件庫

Synthesis of Fe3O4 nanoparticles with various sizes and magnetic properties by controlled hydrolysis
Iida H, et al.
Journal of Colloid and Interface Science, 314(1), 274-280 (2007)
Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system
Neuberger T, et al.
Journal of magnetism and magnetic materials, 293(1), 483-496 (2005)
Antibody conjugated magnetic iron oxide nanoparticles for cancer cell separation in fresh whole blood
Xu H, et al.
Biomaterials, 32(36), 9758-9765 (2011)
Nonpolymeric coatings of iron oxide colloids for biological use as magnetic resonance imaging contrast agents
Portet D, et al.
Journal of Colloid and Interface Science, 238(1), 37-42 (2001)
Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
Peng X, et al.
International journal of nanomedicine, 3(3), 311-311 (2008)

文章

Graphene is a unique two-dimensional (2D) structure of monolayer carbon atoms packed into a dense honeycomb crystal that has attracted great interest due to its diverse and fascinating properties.

Professor Hui Mao explores the use of superparamagnetic iron oxide nanoparticles (INOPs) that offer an alternate contrast-enhancing mechanism.

Hui Mao 教授探討了超順磁氧化鐵奈米粒子 (INOPs) 的使用,它提供了另一種對比增強機制。

Prof. Yadong Yin discusses various synthesis methods of magnetite nanocrystals and their applications in different fields.

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相關內容

Professor Yadong Yin (University of California Riverside, USA) examines both direct (thermal decomposition, solvothermal, hydrothermal) and indirect (templated) synthesis methods of magnetite nanocrystals and reviews in detail the landscape of these various synthetic methods for magnetite nanocrystal and their applications in magnetic assembly, magnetic hyperthermia, and Li-Ion batteries.

Questions

1–7 of 7 Questions  
  1. What is the density of the product ( super paramagnetic iron oxide NP in toluene)

    1 answer
    1. This product is not tested for density. The final concentration of the solution is 5 mg/mL nanoparticles in toluene. However, the density of the iron oxide nanoparticles is ~5.2 g/cm3. The density of 0.865 g/ml listed on the product page is in reference to the toluene, only.

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  2. What is the coating thickness of oleic acid on product number 700312, 700320, and 700304, Iron oxide(II,III), magnetic nanoparticles solution?

    1 answer
    1. The suppliers of the magnetic iron oxide nanoparticles in toluene have indicated that the particles are essentially coated with a monolayer of oleic acid. Since the oleic acid is a long chain hydrocarbon there can exist some folding and irregular structure on the surface.  The suppliers estimate that one should add 1-2 nm to the particle size due to the presence of the oleic acid coating. From this, 1.5 nm is the closest approximation of coating thickness as provided by our suppliers.

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  3. What method is used to determine the size of the particles in Product 700312, Iron oxide?

    1 answer
    1. TEM used to check particle size. Light Scattering or similar methods are not utilized.

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  4. What is the purpose of the oleic acid in Product 700312, Iron oxide? Can it be removed?

    1 answer
    1. Per the manufacturer, the oleic acid allows the iron oxide nanoparticles to be soluble in the solvent (i.e. toluene).

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  5. How should a sample of the Iron oxide(II,III), magnetic nanoparticles solution in toluene be prepared for analysis by transmission electron microscopy (TEM)?

    1 answer
    1. The particle size is determined by TEM.If the solution as provided is not diluted, a superlattice of multilayer nanocrystals will form on the grid, appearing to be an aggregate. The solution can be diluted with the same solvent that it was shipped in (toluene). A solution diluted to 0.1-0.5 mg/mL should be concentrated enough to get a nice picture. One drop per grid should be sufficient. (Since the solution is provided at a concentration of 5 mg/mL, this would be a 10- to 50-fold dilution.)After applying the sample to the grid, a drying time of a minimum of 10-15 minutes is recommended.After performing several successful dilutions and getting good results, the analyst will get a feel for the correct dilution just by judging the color and darkness of the diluted sample. If you see lone isolated dots in the TEM, then your sample is too dilute. If you cannot distinguish separate particles, it is too concentrated. Good record keeping will help to zero in on the best dilution factor for the type of picture that you want.

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  6. How is the magnetization of Product 700312, Iron oxide, determined?

    1 answer
    1. Per the supplier, the magnetization is determined by using a Magnetic Susceptibility Balance.

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  7. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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