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重要文件

561037

Sigma-Aldrich

3,4-二氟苯基溴化镁 溶液

0.5 M in THF

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About This Item

線性公式:
F2C6H3MgBr
CAS號碼:
分子量::
217.29
MDL號碼:
分類程式碼代碼:
12352103
PubChem物質ID:
NACRES:
NA.22
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反應適用性

reaction type: Grignard Reaction

品質等級

濃度

0.5 M in THF

bp

65 °C

密度

0.965 g/mL at 25 °C

官能基

fluoro

儲存溫度

2-8°C

SMILES 字串

Fc1ccc([Mg]Br)cc1F

InChI

1S/C6H3F2.BrH.Mg/c7-5-3-1-2-4-6(5)8;;/h1,3-4H;1H;/q;;+1/p-1

InChI 密鑰

WZHAVYGMKGPNFN-UHFFFAOYSA-M

應用

3,4-Difluorophenylmagnesium bromide can be used:
  • To prepare 3,4-difluorophenylboronic acid, a key building block employed in the synthesis of norepinephrine transporter selective molecules.[1]
  • In the synthesis of trimethoxybenzophenone derived tubulin polymerization inhibitors.[2]
  • In one of the key synthetic steps for the preparation of diarylketoxime derivatives as potent MCH-1R antagonists.[3]
  • In the synthesis of biologically important hydroxybupropion analogs useful in smoking cessation.[4]

法律資訊

Rieke® Metals, Inc. 产品 ®Rieke Metals, Inc. 的注册商标

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

標靶器官

Respiratory system

安全危害

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

1.0 °F - closed cup

閃點(°C)

-17.2 °C - closed cup


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存取文件庫

Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation
Lukas RJ, et al.
Journal of Medicinal Chemistry, 53(12), 4731-4748 (2010)
Synthesis and monoamine transporter binding properties of 3α-(substituted phenyl) nortropane-2β-carboxylic acid methyl esters. Norepinephrine transporter selective compounds
Carroll FI, et al.
Journal of medicinal chemistry, 48(11), 3852-3857 (2005)
Discovery of novel diarylketoxime derivatives as selective and orally active melanin-concentrating hormone 1 receptor antagonists
Suzuki T, et al.
Bioorganic & medicinal chemistry letters, 19(18), 5339-5345 (2009)
2?Amino?3, 4, 5?Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors.
Chuang H Y, et al.
ChemMedChem, 6(3), 450-456 (2011)

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